Korean J Dermatol.  1984 Apr;22(2):148-154.

The Effect of Combination Treatment with Oral Etretinate (Ro 10 - 9359) and Vitamin E on Psoriasis Vulgaris

• Lee SN
• Lee JB
• Cho CK
• Lee HE
• Kim SC
• Kim DH
• Bang DS
• Lee SH
• Park HS
• Kook HI
• Myung KB
• Koh CJ
• Chun SI
• Kim HJ
• Kim DH
• Kim JH

Abstract

Etretinate(Ro 10-9359), an aromatic analogue of vitamin A acid, has been known to be effective in the treatment of psoriasis, Darier's disease, pityriasis rubra pilaris, ichthyosis, and palmoplantar keratoderma when administered orally. In this experiment, we compared the therapeutic and side effects between a group with high dose therapy(initially 75mg of etretinate a day) and an another group with low dose therapy(initially 40mg of etretinate a day). We also observed whether the pretreatment followed by combined treatment with vitamin E could potentiate the therapeutic effect as well as reduce the side effects of oral etretinate. This experiment comprised 102 moderate to severe psoriatic patients. The following results were obtained from this experiment. 1. Fifty-six among 92 patients(61%) who were treated with etretinate for more than 4 weeks showed good to excellent therapeutic effect. 2 The high dose therapy was more effective, but showed more side effects than low dose therapy. 3 Vitamin E did not potentiate the effect of etretinate. In low dose therapy, the pretreatment followed by combined treatment with vitamin E showed a tendency to reduce the side effects of etretinate.

MeSH Terms

Acitretin*
Darier Disease
Etretinate*
Humans
Ichthyosis
Keratoderma, Palmoplantar
Pityriasis Rubra Pilaris
Psoriasis*
Tretinoin
Vitamin E*
Vitamins*
Acitretin
Etretinate
Tretinoin
Vitamin E
Vitamins