Korean J Anesthesiol.  1989 Apr;22(2):315-323. 10.4097/kjae.1989.22.2.315.

Effects of Intravenous Verapamil on Hemodynamics and Pulmonary Gas Exchanges in Isoflurane-N2O-O2 Anesthetized Man

• Kim KS
• Yoo KY
• Im WM
• Ha IH

• KMID: 2240808
• DOI: http://doi.org/10.4097/kjae.1989.22.2.315

Abstract

The purpose of this study was to evaluate the effects of verapamil on hemodynamics and pulmonary gas exchanges during isoflurane-N2O-O2(FIO2, 50%) anesthesia. Hemodynamic measurements and arterial and mixed venous blood gas analyses were made in thirteen healthy patients immediately before (control) and at 1, 5,10min after 5mg of intravenous verapamil administration as single bolus. 1) Verapamil produced a rapid and transient reduction of 15% in mean arterial pressure resulting from a decrease in systemic vascular resistance. 2) Heart rate and cardiac index increased by 14%, 9% respectively only immediately after i.v. verapamil injection and restored thereafter toward control values. 3) SVI, MPAP, PCWP, PVR and CVP revealed only minor changes. 4) Verapamil did not cause any significant changes in intrapulmonary shunt. These findings suggest that during isoflurane-N2O-O2(50%) anesthesia verapamil might safely be used, even in the presence of ventilation/perfusion inequalities, (i.e. lung disease, one lung anesthesia) provided patient has good cardiovascular reserve.

Keyword

Verapamil; Isoflurane

MeSH Terms

Anesthesia
Arterial Pressure
Blood Gas Analysis
Heart Rate
Hemodynamics*
Humans
Isoflurane
Lung
Lung Diseases
Socioeconomic Factors
Vascular Resistance
Verapamil*
Isoflurane
Verapamil