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Comparison of Intralesional Hyaluronic Acid vs. Verapamil for the Treatment of Acute Phase Peyronie’s Disease: A Prospective, Open-Label Non-Randomized Clinical Study

Cocci A, Maida FD, Cito G, Verrienti P, Laruccia N, Campi R, Mari A, Mauro MD, Falcone M, Cacciamani GE, Garaffa G, Minervini A, Russo GI

Purpose: To compare the efficacy and safety of intralesional hyaluronic acid (HA) as compared with verapamil injection in patients with Peyronie’s disease (PD). Materials and Methods: Between January 2015 and December...
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Nitric Oxide Produced by the Antioxidant Activity of Verapamil Improves the Acute Wound Healing Process

Han YN, Lee YJ, Kim KJ, Lee SJ, Choi JY, Moon SH, Rhie JW

BACKGROUND: Verapamil is used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, hypertrophic scars, and keloids to block transmembrane calcium ion flux. Verapamil has antioxidant activity, which enhances the...
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Nimodipine-refractory reversible cerebral vasoconstriction syndrome treated effectively with verapamil

Park SY, Lee JH, Shin IJ, Nogueira RG, Lee JS

Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by recurrent thunderclap headache and reversible multifocal vasoconstrictions of the cerebral arteries. There are no treatment guidelines despite its potential for precarious outcomes....
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Cocktail therapy including bleomycin and verapamil as a promising treatment choice for keloid scars

Park JH, Chang H

Background The treatment of keloids is both challenging and controversial. Until now, there is no definitive treatment modality for keloids. To determine the efficacy and safety of an intralesional cocktail...
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Antinociceptive and anti-inflammatory effects of N-acetylcysteine and verapamil in Wistar rats

Elberry AA, Sharkawi S, Wahba MR

BACKGROUND: Antinociceptive anti-inflammatory drugs have many adverse effects. The goal of this investigation is to study the probable anti-inflammatory and analgesic effects of verapamil and N-acetylcysteine (NAC) in experimental rats. METHODS:...
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The Effect of Intravenous Lipid Emulsion in a Rat Model of Verapamil Toxicity

Ha DM, Kim DH, Kim T, Lee SH, Jeong JH, Lee SB, Lim D, Kang C

PURPOSE: Intravenous lipid emulsion (ILE) has been shown to have significant therapeutic effects on calcium channel blocker overdose in animal studies and clinical cases. In this preliminary experiment, we investigated...
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Effects of Adamantyl Derivatives on Pharmacokinetic Behavior of Paclitaxel in Rats

Kim KM, Lee K, Jang K, Moon YS, Lee HJ, Rhie SJ

Paclitaxel (PTX) is one of the most frequently used anticancer agent for treating refractory ovarian cancer, metastatic breast cancer and non-small cell lung cancer. However, its oral administration is impeded...
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Protective Effects of Verapamil against H2O2-Induced Apoptosis in Human Lens Epithelial Cells

Wang Z, Wang D, Li Y, Zhang X

Verapamil is used in the treatment of hypertension, angina pectoris, and atrial fibrillation. Recently, several studies have demonstrated that verapamil increased the optic nerve head blood flow and improved the...
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Bupivacaine-induced Vasodilation Is Mediated by Decreased Calcium Sensitization in Isolated Endothelium-denuded Rat Aortas Precontracted with Phenylephrine

Ok SH, Bae SI, Kwon SC, Park JC, Kim WC, Park KE, Shin IW, Lee HK, Chung YK, Choi MJ, Sohn JT

BACKGROUND: A toxic dose of bupivacaine produces vasodilation in isolated aortas. The goal of this in vitro study was to investigate the cellular mechanism associated with bupivacaine-induced vasodilation in isolated...
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Effect of Verapamil on Scar Formation in Early Wound Scarring of the Rabbit Ear

Bae TH, Kim WS, Kim HK, Kim MK

  • KMID: 2203117
  • J Korean Soc Plast Reconstr Surg.
  • 2009 Jan;36(1):11-18.
PURPOSE: Excessive scarring in the forms of keloid and hypertrophic scar could be a consequence of the accumulation of granulation tissue cells due to aberrant control of apoptosis. Verapamil retard...
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In Vitro Effects of Nitroglycerin, Nicardipine, Verapamil, and Papaverine on Rabbit Brachial and Celiac Arterial Tone

Shinn SH, Kim YH, Seo JK, Kim JH, Chung WS, Jeon YB, Chang BC, Jang HJ

  • KMID: 2289174
  • Korean J Thorac Cardiovasc Surg.
  • 2008 Oct;41(5):541-549.
BACKGROUND: Vasoconstrictor-induced reduction in arterial graft diameter can cause significant flow deprivation. The aim of this study was to evaluate the effect of vasodilator pretreatment on vasoconstrictor-induced blood vessel spasm...
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Myocardial protective effects of nicorandil and verapamil during ischemia-reperfusion in an isolated perfused rat heart

Kim HS, Cho YK, Kim BS, Kim SO

  • KMID: 2046780
  • Anesth Pain Med.
  • 2008 Oct;3(4):270-276.
BACKGROUND: To reduce or prevent myocardial injury during an ischemia-reperfusion episode, some pharmacological interventions, including administering nicorandil or verapamil, have becomepopular in clinical situations. Nicorandil is a N-(2-hydroxyethyl)- nicotinamide nitrate...
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Effects of Propofol on Phenylephrine Induced Vascular Smooth Muscle Contraction in Rat Thoracic Aorta

Do H, Kim SO, Kim BK, Seo JW

BACKGROUND: Propofol decreases arterial blood pressure. This has been ascribed to vasodilation and decreased cardiac output occuring separately or in combination. The goal of the present study...
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Appropriate Premedication for Prevention on Post-ERCP Pancreatitis: A Randomized and Prospective Study

Yi SY

OBJECTIVES: Pancreatitis is the most common and serious complication of ERCP. On the basis of several reports, corticosteroid, octreotide, or calcium channel blocker might be effective in this regard. The...
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The Effects of Verapamil on Growth and Apoptosis of Keloid Fibroblast

Park JM, Lee KC, Kim SK, Bae HR, Rha SH

  • KMID: 2120040
  • J Korean Soc Plast Reconstr Surg.
  • 2005 Sep;32(5):625-634.
In this study, the effects of verapamil on growth rate, apoptosis, production of transforming growth factor (TGF-beta) and fibronectin were evaluated in keloid and normal human dermal fibroblasts. Both fibroblasts...
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Four Cases of Verapamil Deleterious Effects in Chronic Renal Failure

Park JA, Shin MJ, Hyoung BJ, Park HS, Yoon JM, Choe BS, Yang CW, Kim YS, Kim SY, Bang BK

  • KMID: 2254266
  • Korean J Nephrol.
  • 2005 May;24(3):501-509.
Four hypertensive patients with chronic renal insufficiency who were treated with sustained release verapamil hydrochloride subsequently developed acute toxic effects. All four patients developed marked bradycardia, hypotension, hyperkalemia and metabolic...
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A Case of Fetal Supraventricular Tachycardia with Fetal Ascites Treated by Antiarrhythmic Agent

Shin BS, Cho Y, Ro ES, Lee DO, Mun KS

  • KMID: 2077164
  • Korean J Obstet Gynecol.
  • 2004 Sep;47(9):1794-1799.
We experienced a case of fetal supraventricular tachycardia (SVT) with fetal ascites diagnosed at 29 weeks of gestation in 29 year-old primigravida woman. Transplacental fetal therapy with maternal oral antiarrhythmic...
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The Effect of Magnesium on the Verapamil Neuromuscular Blockade in Rat Phrenic Nerve-Hemidiaphragm Preparations

Lee SI, Lee JH, Kim DY, Kim JY

BACKGROUND: At the neuromuscular junction, magnesium acts on the release of acetylcholine and on the excitability of sarcolemma. Verapamil inhibits acetylcholine release and enhances the autodesensitization of acetylcholine receptor ion...
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The Effect of Simultaneous Steroid and Verapamil Injection on Scar Formation in the Incisional Wound of Rat

Kim YO, Kim SM, Jo NH, Nam TS

  • KMID: 2322342
  • J Korean Soc Plast Reconstr Surg.
  • 2004 May;31(3):375-384.
The wound healing in adult mammals is a complex process that inevitably leaves scar. Various treatment modalities have been investigated to minimize the scar formation, and a few of them...
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Effect of Verapamil on Cellular Uptake of Tc-99m MIBI and Tetrofosmin on Several Cancer Cells

Kim DH, Yoo JA, Bae JH, Jeong SY, Suh MR, Ahn BC, Lee KB, Lee J

  • KMID: 1590235
  • Korean J Nucl Med.
  • 2004 Feb;38(1):85-98.
PURPOSE: Cellular uptake of 99mTc-sestamibi (MIBI) and 99mTc-tetrofosmin (TF) is low in cancer cells expressing multidrug resistance (MDR) by p-glycoprotein (Pgp) or multidrug related protein (MRP). Verapamil is known to...
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