Korean J Anesthesiol.  1992 Apr;25(2):297-301. 10.4097/kjae.1992.25.2.297.

A Comparison between Propofol and Thiopental for Induction of Anesthesia for Elective Caesarean Section

• Choi SJ
• Bae JH
• Han NH
• Son SC

• KMID: 2240581
• DOI: http://doi.org/10.4097/kjae.1992.25.2.297

Abstract

Thiopental sodium has been used in anesthesia of Caesarean section since 1936 and is regarded as the standard induction agent. Propofol has properties which suggest that it might be a useful alternative to thiopental. We compared propofol with thiopental for induction of anesthesia in elective Caesarean section in the present study. Particular attentaion was paid to induction characterisitics and the neonatal effects of both agents. The results were as follows. 1) Side effect during induction were rare in both groups. But both agents caused mild discomfort on injection. 2) There were significant increase in systemic arterial pressure, diastoric pressure and heart rate at postintubation I minute in both groups. But there were no significant differences in cardio vascular response between both groups during the induction. 3) The Apgar scores of the neonates did not differ significantly, and the blood gas analyses of neonates were within the normal range in both groups. We conclude that propofol, in a dose of 2.5 mg/kg, is an acceptable alternative to thiopental for the induction of general anesthesia in Caesarean section.

Keyword

Caesarean section; Propofol; Thiopental

MeSH Terms

Anesthesia*
Anesthesia, General
Arterial Pressure
Blood Gas Analysis
Cesarean Section*
Female
Heart Rate
Humans
Infant, Newborn
Pregnancy
Propofol*
Reference Values
Thiopental*
Propofol
Thiopental