Korean J Anesthesiol.  2000 Jul;39(1):9-13. 10.4097/kjae.2000.39.1.9.

Comparison of Thiopental Sodium and Propofol as Anesthetic Induction Agents for Hypnotic Time

Affiliations
  • 1Department of Anesthesiology, Samsung Hospital, Sungkyunkwan University School of Medicine, Masan, Korea.

Abstract

BACKGROUND: We have used thiopental sodium as an induction agent traditionally, but a recently introduced induction agent, propofol, is gaining popularity among anesthesiologists. The purpose of this study was to compare the difference in induction time by measuring the hypnotic time.
METHODS
Sixty adult patients (ASA class I or II) scheduled for elective surgery under general anesthesia were randomly assigned to receive 5 mg/kg of thiopental (Group I) or 2 mg/kg of propofol (Group II), respectively, as an induction agent. The induction time by using Eyelash reflex (from the start of administration of induction agent to the time of reflex loss) was measured after the administration of thiopental and propofol and compared between these two groups.
RESULTS
The induction time using ER in Group II (52.2 +/- 12.0 s) was not significantly longer than Group I (50.4 +/-9.4 s).
CONCLUSIONS
We concluded that propofol had the same induction time as thiopental for induction of general anesthesia.

Keyword

Anesthetics; intravenous: thiopental sodium; propofol; Induction: anesthesia

MeSH Terms

Adult
Anesthesia, General
Anesthetics
Humans
Propofol*
Reflex
Thiopental*
Anesthetics
Propofol
Thiopental
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