Korean J Anesthesiol.  2001 Mar;40(3):335-339. 10.4097/kjae.2001.40.3.335.

Comparison of Thiopental Sodium and Propofol as an Induction Agent in Propofol-N2O Anesthesia for Cesarean Sections

• Hwang JW
• Oh YS
• Lee HJ

• KMID: 2236803
• DOI: http://doi.org/10.4097/kjae.2001.40.3.335

Abstract

BACKGROUND: We compared thiopental sodium with propofol as induction agents under propofol-N2O anesthesia for cesarean sections.
METHODS
We selected 68 pregnant women with a single fetus undergoing an elective cesarean section under general anesthesia and randomly allocated them to the thiopental sodium group (group N) or the propofol group (group P). Without premedication, thiopental sodium 5 mg/kg and succinylcholine 1 mg/kg were injected for induction in group N, and propofol 2 mg/kg and succinylcholine 1 mg/kg in group P. Propofol 10 mg/kg/hr was infused continuously with 50% N2O in both groups. We checked the blood pressure and the heart rate before and after injection. We analysed blood gas of maternal artery, umbilical artery, and umbilical vein at delivery and checked Apgar scores at 1 minute and 5 minutes after delivery.
RESULTS
There was no significant difference in blood pressure, heart rate and Apgar scores between groups. Oxygen partial pressure (35.6 +/- 5.8 mmHg) and oxygen saturation (66.2 +/- 12.0%) of the umbilical vein in group P was higher than in group N (32.7 +/- 4.9 mmHg, 58.7 +/- 11.5%). Carbon dioxide partial pressure and pH did not differ between groups.
CONCLUSIONS
There was no beneficial effect of thiopental sodium compared with propofol as an induction agent under propofol anesthesia. Propofol is a useful drug for cesarean sections.

Keyword

Anesthesia: obstetric; Anesthetics, intravenous: propofol; thiopental sodium

MeSH Terms

Anesthesia*
Anesthesia, General
Arteries
Blood Pressure
Carbon Dioxide
Cesarean Section*
Female
Fetus
Heart Rate
Humans
Hydrogen-Ion Concentration
Oxygen
Partial Pressure
Pregnancy
Pregnant Women
Premedication
Propofol*
Succinylcholine
Thiopental*
Umbilical Arteries
Umbilical Veins
Carbon Dioxide
Oxygen
Propofol
Succinylcholine
Thiopental