Korean J Anesthesiol.  1994 Oct;27(10):1373-1377. 10.4097/kjae.1994.27.10.1373.

The Circulatory Effect of Pheniramice Malate at Initial Period of Extracorporeal Circulation in Pediatric Open Heart Surgery

• Kim SK
• Lee SM
• Lee GW
• Kim YL

• KMID: 2240510
• DOI: http://doi.org/10.4097/kjae.1994.27.10.1373

Abstract

Plasma protein derivatives such as plasms protein fraction and 5% albumin are popular pump primes in extracorporeal circulation. But, the use of plasma protein fraction is in s dilemma due to its hypotensive effect. The aim of this study is to evaluate the effects of plasma protein fraction on arterial pressure and central venous pressure as one of the components of priming solution. And also in order to assess the role of histamine indirectly as a possible vssodepressive substance causing hypotension, we used one of the antihistamines as a indirect indicator. Fourty pediatric eardiac patients undergoing cardiopulmonary bypass were randomly assigned to two groups as with or without pheniramine malate and plasma protein fraction 250ml was mixed in priming solution in all cases. Mean arterial snd central venous pressure were checked just before cardiopulmonary bypass(baseline) and every one minute after pump on for 5 minutes. Pheniramine malate, 0.75mg/ kg, was added in prime solution 10 minutes before pump on to twenty patients and not the other twenty patients. In both groups, mean arterial pressure at the beginning of pump showed significant decrease (P<0.05) from baseline. But there were no differences between two groups. Central venous pressure showed no significant chsnge between groups and intra group. These data suggest that other plasma expander other than plasma protein fraction should be considered for prime in pediatric cardiac surgery and other vasodepressive materials than histamine may play major role in inducing hypotension.

Keyword

Cardiac anesthesia; Plasma protein fraction; Hypotension; Antihistamine

MeSH Terms

Arterial Pressure
Cardiopulmonary Bypass
Central Venous Pressure
Extracorporeal Circulation*
Heart*
Histamine
Histamine Antagonists
Humans
Hypotension
Pheniramine
Plasma
Thoracic Surgery*
Histamine
Histamine Antagonists
Pheniramine