Korean J Anesthesiol.  1998 Sep;35(3):583-588. 10.4097/kjae.1998.35.3.583.

Suspicious Malignant Hyperthermia in Child during General Anesthesia: A case report

• Ha KH
• Lee SS
• Yon JH
• Hong KH

• KMID: 2240152
• DOI: http://doi.org/10.4097/kjae.1998.35.3.583

Abstract

We had a 16-month-old male presented for a surgery for degloving injury of left lower extremity. He had no considerable past or family history. High fever and increased end-tidal CO2 with tachycardia was revealed after induction of general anesthesia with thiopental sodium, vecuronium, isoflurane-N2O and O2. Arterial blood gas analysis showed a severe mixed acidosis. Under the suspicion of malignant hyperthermia, all anesthetics were discontinued. Anesthesia was maintained with fentanyl and midazolam. The patient was managed with surface cooling, gastric lavage with cold saline, sodium bicarbonate and diuretics. Dantrolene sodium 50 mg was administered. The patient survived without any sequelae and discharged after 9 days. The etiologic factors, incidence, clinical features, prevention and treatments of malignant hyperthermia are discussed.

Keyword

Hyperthermia: malignant; Pharmacology: vecuronium; isoflurane; dantrolene sodium

MeSH Terms

Acidosis
Anesthesia
Anesthesia, General*
Anesthetics
Blood Gas Analysis
Child*
Dantrolene
Diuretics
Fentanyl
Fever
Gastric Lavage
Humans
Incidence
Infant
Lower Extremity
Male
Malignant Hyperthermia*
Midazolam
Sodium Bicarbonate
Tachycardia
Thiopental
Vecuronium Bromide
Anesthetics
Dantrolene
Diuretics
Fentanyl
Midazolam
Sodium Bicarbonate
Thiopental
Vecuronium Bromide