Korean J Anesthesiol.
1999 May;36(5):841-845. 10.4097/kjae.1999.36.5.841.
A Comparison of the Effect of Nalbuphine-Ketorolac and Morphine-Fentanyl-Ketorolac for Postoperative Analgesia with the Use of IV-PCA
- Affiliations
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- 1Department of Anesthesiology, Choi Hospital.
- 2Department of Anesthesiology, College of Medicine, Chungbuk National University, Cheongju, Korea.
- KMID: 2240075
- DOI: http://doi.org/10.4097/kjae.1999.36.5.841
Abstract
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BACKGROUND: Intravenous patient-controlled analgesia (IV-PCA) is a safe and effective method for post-operative pain control. But opioids used in IV-PCA result in some side effects such as respiratory depression, nausea, vomiting, itching and urinary retention. Nalbuphine, an agonist-antagonist, has a considerable analgesic effect without serious complications. This study was designed to evaluate the effectiveness of post-operative pain relief in PCA-administered nalbuphine-ketorolac and morphine-fentanyl-ketorolac.
METHODS
Patients scheduled for total abdominal hysterectomy were randomly assigned in a double-blind manner into one of two groups. Group 1 (n=24) and Group 2 (n=28) received nalbuphine-ketorolac or morphine-fentanyl-ketorolac, respectively. All patients received same background infusion rate (2 ml/hr), PCA dose (0.5 ml) and lockout interval (15 min) just after peritoneum closure. And post-operative pain scores were recorded with numerical rating scale (NRS) at 1, 2, 6, 12, 24 and 48 hr after operation.
RESULTS
The pain control effect in group 1 was more effective than in group 2. The patients' satisfaction was more superior in group 1. And the number of using PCA button was more frequent in group 2.
CONCLUSION
This study suggests that intravenous nalbuphine is an excellent alternative to morphine and fentanyl for postopertive pain control.
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