Korean J Lab Med.  2006 Jun;26(3):143-145. 10.3343/kjlm.2006.26.3.143.

A Granulocytic Sarcoma of Right Uterine Adnexa Region as an Extramedullary Relapse in a Patient with Chronic Myeloid Leukemia

• Cho YG
• Lee JH
• Lee NR
• Kim DS
• Lee HS
• Choi SI

• KMID: 2238878
• DOI: http://doi.org/10.3343/kjlm.2006.26.3.143

Abstract

Granulocytic sarcoma of the uterine adnexa is a rare event. A 50-year-old woman, who had previously been diagnosed as chronic myeloid leukemia (CML), but had a complete hematologic response, presented with lower abdominal pain and a large pelvic mass involving the right uterine adnexa region and extending to the right posterior wall of the bladder and right distal ureter. A biopsy of the uterine adnexa revealed granulocytic sarcoma, and a subsequent bone marrow biopsy confirmed the diagnosis of CML in the blastic phase.

Keyword

Granulocytic sarcoma; Adnexa uteri; Chronic myelogenous leukemia

MeSH Terms

Abdominal Pain
Adnexa Uteri
Biopsy
Bone Marrow
Diagnosis
Female
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
Middle Aged
Recurrence*
Sarcoma, Myeloid*
Ureter
Urinary Bladder

Figure

• 

  Fig. 1. MRI of the pelvis with enhancement shows a mass of the right uterine adnexa region with a size of 6.5×6.0 cm infiltrating the wall of the bladder and uterus.

• 

  Fig. 2. Biopsy pictures of the uterine mass. (A) H&E stain, ×400, show the infiltrating leukemic blasts. The granulocytic cells are positive with immunohistochemical stain for anti-CD68 (B) and lysozyme (C), focal positive for c-kit (CD117) (D) (×400).

• 

  Fig. 3. Blood pictures in (A) peripheral blood smear (×1,000) and (B) bone marrow biopsy (×400). All findings are consistent with chroninc myeloid leukemia in blastic phase.

Reference

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