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A Novel Four-Way Translocation t(5;9;22;18)(q31;q34;q11.2;q21) in a Patient with Chronic Myelogenous Leukemia

Kim WS, Park G, Jang SJ, Moon DS, Kang SH

Chronic myelogenous leukemia (CML) is characterized by the presence of the Philadelphia chromosome, which is generated by a reciprocal t(9;22)(q34;q11) translocation. Variant Philadelphia chromosomes, found in 5-10% of CML cases,...
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Characteristics of hematologic malignancies with coexisting t(9;22) and inv(16) chromosomal abnormalities

Han E, Lee H, Kim M, Kim Y, Han K, Lee SE, Kim HJ, Kim DW

BACKGROUND: The coexistence of t(9;22)(q34;q11.2) and inv(16)(p13q22) chromosomal abnormalities is extremely uncommon, and only a small number of such cases have been reported. Here, we characterized 7 cases of hematologic...
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Efficacy of imatinib mesylate-based front-line therapy in pediatric chronic myelogenous leukemia

Oh HJ, Cho MS, Lee JW, Jang PS, Chung NG, Cho B, Kim HK

PURPOSE: Despite the established role of imatinib (IM) in chronic myelogenous leukemia (CML) in adults, there are few reports on its efficacy in children. In this study, we compared the...
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Imatinib Mesylate is Effective for Patients Not Only with Chronic Myeloid Leukemia, but Also Rheumatoid Arthritis

Jung HJ, Kim DH, Song R, Hong SJ, Yang HI, Eo WK, Lee SH

  • KMID: 2263467
  • Korean J Med.
  • 2012 Sep;83(3):405-410.
Synovial tissue proliferation and inflammation are regarded as possible causes of rheumatoid arthritis. Activation of tyrosine kinase by numerous cytokines and BCR-ABL translocation contribute to synovial tissue inflammation and the...
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Efficacy of Imatinib Mesylate Treatment for a Patient with Rheumatoid Arthritis and Who Developed Chronic Myelogenous Leukemia

Jeon HK, Park YE, Kim SI, Park SH, Baek SH, Lee JW, Ha DW, Lee HW, Chung JS, Lee SH, Lee EY

  • KMID: 2391939
  • J Rheum Dis.
  • 2011 Jun;18(2):118-121.
Rheumatoid arthritis is associated with an increased risk of hematological malignancy as a result of the RA itself or its treatment. We report here on an unusual case of a...
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The treatment of pediatric chronic myelogenous leukemia in the imatinib era

Lee JW, Chung NG

Childhood chronic myelogenous leukemia (CML) is a rare hematologic disease, with limited literature on the methods of treatment. Previously, allogeneic hematopoietic stem cell transplantation (HSCT) was considered the only curative...
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A Case of Ankylosing Spondylitis Accompanied by Chronic Myelogenous Leukemia

Choi WH, Ji EH, Lee JH, Kim SW, Min JS, Park HW, Jun BY, Jeong YO, Park KS, Park SH, Kim HY

Ankylosing spondylitis (AS) is occasionally accompanied by hematological malignancies such as myelodysplastic syndrome, acute myelogenous leukemia, or multiple myeloma. Chronic myelogenous leukemia (CML) is a myeloproliferative disorder associated with Philadelphia...
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Extramedullary B Lymphoblastic Crisis of CML, Presenting as a Leptomeningeal Tumor: A Case Report

Jeong H, Shin B, Bae SY, Lee S, Ryu Y, Kim H, Kim I

We report here on a rare case of a patient who presented with an extramedullary B lymphoblastic crisis as an initial manifestation of chronic myelogenous leukemia (CML). A 71-year-old man...
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Retinal Vasculopathy as First Manifestation of Chronic Myelogenous Leukemia

Kim IT, Kwon JW

PURPOSE: To present a case of bilateral retinal vasculopathy as the first manifestation of chronic myelogenous leukemia. CASE SUMMARY: A 59-year-old man with no medical history such as diabetes, hypertension...
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Mutation of the N-ras Gene in a Patient Suffering from the Blast Phase of Chronic Myelogenous Leukemia

Song SH, Roh YW, Ahn YW, Kim YJ, Byoun YS, Choi JY, Hwang DW, Park BB, Choi JH, Kim IS, Kim BK, Lee YY

The blast phase in chronic myelogenous leukemia (CML) is associated with mutation of several genes. It is well known that p53 gene mutation plays a key role in the myeloid...
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Endoscopic Submucosal Dissection of Early Gastric Cancer That Occurred in a Patient with Chronic Myelogenous Leukemia

Hwangbo Y, Jang JY, Shim J, Dong SH, Kim HJ, Kim BH, Chang YW, Chang R

  • KMID: 2304772
  • Korean J Gastrointest Endosc.
  • 2009 May;38(5):288-293.
Synchronous double malignancies of early gastric cancer and chronic myelogenous leukemia (CML) are very rare. There are few reports regarding the effect of the CML or imatinib on stomach cancer,...
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The Cytologic Features of Chronic Myelogenous Leukemia and Its Lymphoid Blast Phase in Body Fluid: A Case Report

Im S, Yoo C, Lee YS, Kang CS, Sim SI, Lee KY

  • KMID: 2073803
  • Korean J Pathol.
  • 2009 Apr;43(2):189-194.
Although chronic myelogenous leukemia (CML) may be involved in any part of the body, infiltration of the body fluid has rarely reported in the literature. Here we report on a...
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A Case of Juvenile Xanthogranuloma Developed in a Neurofibromatosis Child with Family History

Seo HD, Song JY, Chung BS, Choi KC, Shin BS

  • KMID: 2302064
  • Korean J Dermatol.
  • 2008 Apr;46(4):547-549.
Juvenile xanthogranuloma (JXG) is a fibrohistiocytic proliferative disorder predominant in infancy and childhood. It is a benign and transient skin lesion that usually appears in the cephalic area. Recently, the...
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Chronic Myelogenous Leukemia with a Variant Philadelphia Translocation: t(11;22)(q25;q11.2)

Kim HS, Cho HC, Kim SH, Moon Y, Nahm CH, Choi JW, Kim JJ

We report a case of chronic myelogenous leukemia displaying a variant Philadelphia translocation t(11;22)(q25;q11.2). Breakpoint 11q25 has not previously been reported. Reverse transcriptase polymerase chain reaction and fluorescence in-situ hybridization...
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A Granulocytic Sarcoma of Right Uterine Adnexa Region as an Extramedullary Relapse in a Patient with Chronic Myeloid Leukemia

Cho YG, Lee JH, Lee NR, Kim DS, Lee HS, Choi SI

Granulocytic sarcoma of the uterine adnexa is a rare event. A 50-year-old woman, who had previously been diagnosed as chronic myeloid leukemia (CML), but had a complete hematologic response, presented...
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A Case of Chronic Radiodermatitis with CML and Squamous Cell Carcinoma in Radiologist

Kim DH, Kim HS, Lee JY, Park HJ, Cho BK

Chronic radiodermatitis may develop after repetitive exposure to small doses of ionizing radiation over an extensive period of time. Therefore, it is most likely to occur in people who work...
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Reversal of Marrow Fibrosis Following Imatinib Mesylate Therapy in a Patient with Chronic Myelogenous Leukemia Who Was Refractory to Interferon-alpha

Kim YS, Kim TH, Kim WC, Jeon YJ, Kil UH, Lee HK, Kim YS, Rho SY, Cho SG

No abstract available.
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Clinical Resistance to the Tyrosine Kinase Inhibitor Imatinib (STI571) and Detection of BCR-ABL Gene Mutations in Korean Patients with Chronic Myeloid Leukemia

Sohn YH, Chi HS, Park CJ, Lee KH, Seo EJ

BACKGROUND: Imatinib mesylate, the tyrosine kinase activity of the BCR-ABL fusion gene, induces a remarkable remission in chronic myeloid leukemia (CML) patients. However, resistance to imatinib has been observed in...
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Renal Involvement of Chronic Myelogenous Leukemia Presenting as a Kidney Tumor

Go JH

Renal involvement by leukemic cells is rare in chronic myelogenous leukemia (CML). Herein, this study reports a case of CML associated with renal involvement of leukemic cells, which occurred 1...
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A Case of Chronic Myelogenous Leukemia with Abnormal Expression of N-CAM (CD56) Adhesion Molecule on CD34-negative Non-blastic Myeloid Cells

Lee KA, Ryu S, Kim KH, Cho Y, Kim YK, Kim BS

  • KMID: 2239109
  • Korean J Lab Med.
  • 2004 Feb;24(1):1-6.
The CD56 antigen is a cell adhesion molecule and its expression on tumor cells is thought to play a role in CD56-positive lymphomas and leukemias with unusual sites of involvement....
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