Ann Dermatol.  2011 Oct;23(Suppl 2):S270-S273. 10.5021/ad.2011.23.S2.S270.

Multiple Granulocytic Sarcomas in a Patient with Longstanding Complete Remission of Acute Myelogenous Leukemia

  • 1Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.


Granulocytic sarcoma is an extramedullary tumor composed of granulocytic precursor cells. It usually presents as a nodular mass in the course of acute myelogenous leukemia. Rarely, the tumor develops in non-hematological conditions or in a patient with complete remission from the acute myelogenous leukemia. In such cases, aleukemic granulocytic sarcoma can be a preceding sign of systemic leukemia or a first sign of hematologic relapse of leukemia. We present an unusual case of multiple granulocytic sarcomas developed in a patient with longstanding complete remission of acute myelogenous leukemia, who has not had bone marrow and peripheral blood involvement for a long time.


Aleukemic leukemia cutis; AML M1; Granulocytic sarcoma

MeSH Terms

Bone Marrow
Granulocyte Precursor Cells
Leukemia, Myeloid, Acute
Sarcoma, Myeloid


  • Fig. 1 (A, B) Widespread well-demarcated variable-sized greenish firm cutaneous nodules over the face, trunk and extremities.

  • Fig. 2 (A) Dense cellular infiltrate among collagen bundles and in the perifollicular areas within the entire dermis (H&E, original magnification ×40). (B) Higher magnification reveals homogenous atypical cells with round to oval shaped hyperchromatic nuclei (H&E, original magnification ×400).

  • Fig. 3 (A) Tumor cells are positive for Leder stain and immunoperoxidase (original magnification ×400). (B) Tumor cells are negative for CD3, CD20, CD34, TdT and Pax-5 (original magnification ×40).


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