Korean J Med.  2016 Feb;90(2):159-162. 10.3904/kjm.2016.90.2.159.

Chronic Myeloid Leukemia Relapsing as Isolated Extramedullary Disease Presenting as a Cardiac Mass

• Byeon S
• Kim HK
• Moon JH
• Moon SM
• Park JE
• Park S
• Jung CW

• KMID: 2268876
• DOI: http://doi.org/10.3904/kjm.2016.90.2.159

Abstract

Allogeneic hematopoietic stem cell transplantation is the only option for chemotherapy-refractory chronic myeloid leukemia (CML). Extramedullary relapse after transplantation is rare and usually accompanies marrow relapse. Generally, the prognosis of extramedullary relapse is poor. Here, we report a man with extramedullary relapsed CML after stem cell transplantation that presented as an isolated cardiac mass, which has shown an indolent course for more than 2 years, without evolving to medullary relapse during that period. This case implies that the CML clone might contribute to the development of quiescent extramedullary relapse with a benign course.

Keyword

Chronic myeloid leukemia; Granulocytic sarcoma; Cardiac tumor

MeSH Terms

Bone Marrow
Clone Cells
Heart Neoplasms
Hematopoietic Stem Cell Transplantation
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
Prognosis
Recurrence
Sarcoma, Myeloid
Stem Cell Transplantation