Korean J Anesthesiol.  1991 Oct;24(5):925-930. 10.4097/kjae.1991.24.5.925.

Behamioral Change and Memory Inpairment Following Transient Forebrain Ischemia in Rats

• Rho CK
• Kwon JY
• Kim HK
• Baik SW
• Kim IS
• Chung KS

• KMID: 2237088
• DOI: http://doi.org/10.4097/kjae.1991.24.5.925

Abstract

This study examined the behavioral change and memory impairment following transient forebrain ischemia in 20 male rats: ten rats were subjected to sham operation. Inchemia was induced by a combination of bilateral common carotid artery occlusion and induced hypotension. During the recovery period, behavioral change was evaluated by open-field method. Histopathological examination was performed 7 days after ischemic insult. The results were as follows 1) Hippocampus CA 1 neuron was the most vulnerable to 10-minute forebrain ischemia. 2) There was increase in locomotor activity and rearing during early post-ischemic period. 3) Ischemia resulted in suppressed preening and grooming. From the above mentioned results, authors suggested that transient forebrain ischemia produced severe neuronal damage in CA l sector of hippocampus, therefore produced behavioral change and memory impairment.

Keyword

Transient forebrain ischemia; Open field test

MeSH Terms

Animals
Carotid Artery, Common
Grooming
Hippocampus
Humans
Hypotension
Ischemia*
Male
Memory*
Motor Activity
Neurons
Prosencephalon*
Rats*