Korean J Psychopharmacol.  2006 Nov;17(6):565-572.

The Effect of Fluoxetine on Behaviors in Transient Forebrain Ischemic Gerbil

• Li H
• Kim DH
• Won MH
• Yan JJ

Abstract

OBJECTIVE
This study aims to explore the effect of fluoxetine on memory, locomotor and depressive behavior in transient forebrain ischemic model of gerbil.
METHODS
Doses of fluoxetine (10, 40 mg/kg) or vehicle were intraperitoneally administered once 30 min before ischemic surgery in gerbil. Novel object recognition test, spontaneous motor activity, learned helplessness test were performed 4 days, 8 days, or 9 days, respectively, after sham or ischemic surgery.
RESULTS
Fluoxetine treatment (40 mg/kg) significantly reduced recognition memory in sham operated gerbil. However, fluoxetine (10, 40 mg/kg) did not affect ischemia-induced impairment in recognition memory. The treatment of fluoxetine (10, 40 mg/kg) significantly inhibited locomotor hyperactivity induced by transient ischemia even though fluoxetine (40 mg/kg) did not affect spontaneous motor activity in the sham operated gerbils. Fluoxetine did not affect depressive behavior in sham and ischemic gerbils.
CONCLUSION
The treatment of fluoxetine inhibited ischemia-induced hyperactivity, but did not affect memory and depressive behavior in transient forebrain ischemic gerbils.

Keyword

Transient forebrain ischemia; Fluoxetine; Novel object recognition test; Spontaneous motor activity; Learned helplessness test