Korean J Anesthesiol.  1992 Feb;25(1):72-77. 10.4097/kjae.1992.25.1.72.

The Effect of Venovenous Extracorporeal Lung Assist on the Arterial Oxygen Tension in Hypoxic Dogs

• Lee KH
• Ham BM
• Jung SE

• KMID: 2237035
• DOI: http://doi.org/10.4097/kjae.1992.25.1.72

Abstract

Neonatal venoarterial(VA) extracorporeal lung assist(ECLA) drains venous blood from the right atrium via the right internal jugular vein and perfuses oxygenated blood to the aortic arch via the right common carotid artery. Though VA ECLA supports cardiac function, it is not free from neurologic complications due to ligation of the carotid artery. Venovenous(VV) bypass is used early for acute respiratory failure. To reduce the number of veins ligated, a double lumen tube was developed. VV ECLA using the double lumen tube was tried on eight hypoxic dogs at F1O2 0.15. Control values of hemodynamics and blood gases were obtained while the 0.8 m kolobow lung ventilated with nitrogen gas. We measured the same parameters while ventilating the oxygenator with oxygen(ECLA on). Mean arterial pressure and mean pulmonary arterial pressure were decreased significantly during ECLA on. Bypass flow rate was 1042+/-72ml/min and bypass ratio(bypass flow rate cardiac output X100) was 40+/-15%. Arterial oxygen tension was increased from 52+/-14mmHg to 79+/-23mmHg during ECLA on, whose saturation was 94+/-2%. Venous drainage was limited with a double lumen tube, but it can be used clinically for moderate hypoxemia with ease.

Keyword

Venoarterial(VA); Extracorporeal lung assist(ECLA); Venovenous(VV); Double Lumen tube; Bypass flow rate; Bypass ratio; Hypoxemia

MeSH Terms

Animals
Anoxia
Aorta, Thoracic
Arterial Pressure
Cardiac Output
Carotid Arteries
Carotid Artery, Common
Dogs*
Drainage
Gases
Heart Atria
Hemodynamics
Jugular Veins
Ligation
Lung*
Nitrogen
Oxygen*
Oxygenators
Respiratory Insufficiency
Veins
Gases
Nitrogen
Oxygen