Korean J Fam Med.  2010 Aug;31(8):600-606. 10.4082/kjfm.2010.31.8.600.

The Role of Mean Platelet Volume as a Predicting Factor of Asymptomatic Coronary Artery Disease

• Chang HA
• Hwang HS
• Park HK
• Chun MY
• Sung JY

• KMID: 2234648
• DOI: http://doi.org/10.4082/kjfm.2010.31.8.600

Abstract

BACKGROUND
Platelet has been known as an implicating factor in the pathophysiology of atherosclerotic disease. Larger platelets are more reactive and produce more prothrombotic factors. Several studies have shown relationship between mean platelet volume (MPV) and coronary artery disease. The present study has been designed to investigate association of MPV and subclinical CAD (coronary artery disease; abnormal finding in coronary multidetector computed tomography [MDCT] in asymptomatic individual).
METHODS
This cross sectional study was carried out in 103 men and 72 women (over 40 years old) who underwent coronary MDCT as screening test for disease prevention in the health examination center of Hanyang University Medical Center in Korea from January 1 to April 30, 2009. Subclinical CAD was defined when either of the following findings are present in asymptomatic patients: 1) plaque or calcification, 2) stenosis of any level. After adjustment for age, gender, hypertension, diabetes, BMI, smoking (pack-years), LDL cholesterol, odds ratios (ORs) for the prevalence of the subclinical CAD were calculated for quintiles of MPV using logistic regression analysis.
RESULTS
After adjustment for age, gender, hypertension, diabetes, BMI, smoking (pack-years), LDL cholesterol, the OR for subclinical CAD, comparing the fifth quintile of MPV with the first quintile, was 5.83 (95% confidence interval, 1.51 to 22.42; P = 0.010).
CONCLUSION
Highest level of MPV is independently associated with the prevalence of the subclinical CAD after adjusting for other risk factors.

Keyword

Mean Platelet Volume; Coronary Artery Disease; Platelet; Atherosclerosis; Coronary Multidetector Computed Tomography

MeSH Terms

Academic Medical Centers
Arteries
Atherosclerosis
Blood Platelets
Cholesterol, LDL
Constriction, Pathologic
Coronary Artery Disease
Coronary Vessels
Female
Humans
Hypertension
Korea
Logistic Models
Male
Mass Screening
Multidetector Computed Tomography
Odds Ratio
Prevalence
Risk Factors
Smoke
Smoking
Cholesterol, LDL
Smoke