Korean Circ J.  1997 Nov;27(11):1082-1086. 10.4070/kcj.1997.27.11.1082.

Genetic Polymorphism of a Platelet Glycoprotein IIIa as anInherited Risk Factor for Coronary Artery Disease in Koreans

• Kim GY
• Kim DS
• Kwon HM
• Kim HS

• KMID: 2029439
• DOI: http://doi.org/10.4070/kcj.1997.27.11.1082

Abstract

BACKGROUND
Platelet aggregation and thrombus formation within the coronary artery are major factors in acute coronary syndrome. The platelet glycoproteinIIb/IIIa receptor is a pivotal mediator of platelet aggregation. Recently there have been reports that the genetic polymorphism of GPIIIa is an inherited risk factor for coronary artery thrombosis. This study investigated the relation between the Pl(A) polymorphism and coronary artery disease in Korean patients.
METHODS
One hundred patients with acute myocardial infarction and unstable angina were enrolled. Coronary angiogram was performed in eighty-one cases. Genomic DNA from peripheral blood was amplified by polymerase chain reaction. Allele-specific restriction digestion was used to determine the Pl(A) genotype.
RESULTS
AND CONCLUSIONS: The prevalence of Pl(A2) genotype was zero percent in our study group. All patients had the Pl(A1/A1) genotype. These results suggest that Pl(A) genetic polymorphism of GPIIIa is not an inherited risk factor for coronary artery diseases in Koreans.

Keyword

Platelet GlycoproteinIIb/IIIa receptor; GPIIIa genetic polymorphism; Risk factor for coronary artery disease

MeSH Terms

Acute Coronary Syndrome
Angina, Unstable
Blood Platelets*
Coronary Artery Disease*
Coronary Vessels*
Digestion
DNA
Genotype
Humans
Integrin beta3*
Myocardial Infarction
Platelet Aggregation
Polymerase Chain Reaction
Polymorphism, Genetic*
Prevalence
Risk Factors*
Thrombosis
DNA
Integrin beta3