Yonsei Med J.  2004 Jun;45(3):428-434. 10.3349/ymj.2004.45.3.428.

Association of the Gene Polymorphisms of Platelet Glycoprotein Ia and IIb/IIIa with Myocardial Infarction and Extent of Coronary Artery Disease in the Korean Population

• Park S
• Park HY
• Park C
• Ko YG
• Im EK
• Jo I
• Shin C
• Lee JB
• Shim WH
• Cho SY
• Jang Y

• KMID: 1734124
• DOI: http://doi.org/10.3349/ymj.2004.45.3.428

Abstract

Platelet membrane receptor glycoproteins (GP) are essential for the platelet activation process, and the genetic polymorphisms in the genes that encode platelet glycoproteins have been proposed to influence the risk of acute coronary syndrome and atherosclerosis. In this study, we investigated the role of GPIa, HPA-1 and HPA-3 polymorphisms as putative risk factors for myocardial infarction (MI) and the extent of coronary artery disease. We selected 1, 073 subjects who underwent coronary angiography; 242 had normal or minimal coronary atherosclerosis, and 831 patients had significant coronary artery disease (CAD). The genotype was determined by the methods of single base extension for C807T/G873A polymorphisms of GPIa, and restriction fragment length polymorphism for HPA-1 and HPA-3. The C807T and G873A polymorphisms of GPIa showed complete linkage in the Korean population. For HPA-1 gene polymorphism, only the HPA-1a/a (PlA1/A1) genotype was observed in 192 selected subjects from our study population. The distribution of GPIa (C807T/G873A) and HPA-3 genotypes did not differ significantly between normal subjects and CAD subjects. No significant association between MI and both gene polymorphisms was present. However, for the subgroup analysis of young male patients whose age was less than 56 years, the genotype frequency of HPA-3b/b was significantly lower in patients with MI compared to patients without a history of MI (7.5% vs. 20.0%, p=0.04). The odds ratio for HPA-3 b homozygosity versus the HPA-3a carrier was 0.32 (95% CI, 0.10- 0.99, p=0.04). Conclusively, HPA-3 polymorphism was associated with MI in Korean individuals younger than 56 years of age, but other polymorphisms of GP, which we studied, were not associated with both the extent of coronary atherosclerosis or MI.

Keyword

Polymorphism; genetics; platelet membrane glycoproteins; myocardial infarction; coronary artery disease; Koreans

MeSH Terms

Aged
Coronary Arteriosclerosis/epidemiology/*genetics
Female
Gene Frequency
Genetic Predisposition to Disease/epidemiology
Genotype
Human
Integrin alpha2/*genetics
Integrin beta3/*genetics
Korea
Male
Middle Aged
Myocardial Infarction/epidemiology/*genetics
Platelet Membrane Glycoprotein IIb/*genetics
*Polymorphism (Genetics)
Risk Factors
Support, Non-U.S. Gov't