Int Neurourol J.  2014 Mar;18(1):23-30.

Clinical Factors Associated With Dose Escalation of Solifenacin for the Treatment of Overactive Bladder in Real Life Practice

• Chun JY
• Song M
• Han JY
• Na S
• Hong B
• Choo MS

Abstract

PURPOSE
To determine the baseline clinical characteristics associated with dose escalation of solifenacin in patients with overactive bladder (OAB).
METHODS
We analyzed the data of patients with OAB (micturition frequency > or =8/day and urgency > or =1/day) who were treated with solifenacin and followed up for 24 weeks. According to our department protocol, all the patients kept voiding diaries, and OAB symptom scores (OABSS) were monitored at baseline and after 4, 12, and 24 weeks of solifenacin treatment.
RESULTS
In total, 68 patients (mean age, 60.8+/-10.0 years) were recruited. The dose escalation rate by the end of the study was 41.2%, from 23.5% at 4 weeks and 17.6% at 12 weeks. At baseline, the dose escalator group had significantly more OAB wet patients (53.6% vs. 20.0%) and higher total OABSS (10.2+/-2.4 vs. 7.9+/-3.5, P=0.032) than the nonescalator group. OAB wet (odds ratio [OR], 4.615; 95% confidence interval [CI], 1.578-13.499; P<0.05) and total OABSS (OR, 1.398; 95% CI, 1.046-1.869; P<0.05) were found to be independently associated with dose escalation.
CONCLUSIONS
Patients who have urgency urinary incontinence and high total OABSS have a tendency for dose escalation of solifenacin.

Keyword

Overactive urinary bladder; Muscarinic antagonists; Solifenacin

MeSH Terms

Elevators and Escalators
Humans
Muscarinic Antagonists
Solifenacin Succinate
Urinary Bladder, Overactive*
Urinary Incontinence
Muscarinic Antagonists