Korean J Dermatol.  1986 Oct;24(5):586-593.

Epidermal Changes with Ultraviolet Irradiation and PUVA Treatment in the Black Mouse

• Han KW
• Han HK
• Myung KB
• Kook HI

Abstract

The pretent study was performed to study the epiderrnal changes of ultraviolet irradiation and PUVA treatment in the black mice. The following results were obtained: 1) The histologic changes of the epidermis, number of DOPA positive melanocytes and ultrastructural changes of keratinocytes due to UVB and PUVA were rnore prominent than those of UVA irradiation. 2) The histological changes after 8-MOP photosensitization closely mirnic those of UVR irradiation, and constant, finding was hyperkeratosis. 3) Early histological change after UVL irradiation & IUVA treatment was appearance of dytkeratotic cells. 4) Pro]onged exposure to UVB & PUVA resulted in transient epidermal hyperplasia, and epidermal atrophy occurred 3 weeks after PUVA treatment. 5) Early electron microscopic changes was perinuclear edema, juxtanuclear vacuoles and clumping of tonofilament.

Keyword

UV light; PUVA; Epidermal change

MeSH Terms

Animals
Atrophy
Dihydroxyphenylalanine
Edema
Epidermis
Hyperplasia
Intermediate Filaments
Keratinocytes
Melanocytes
Methoxsalen
Mice*
Photosensitivity Disorders
Ultraviolet Rays
Vacuoles
Dihydroxyphenylalanine
Methoxsalen