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Interleukin-6, S-Nitrosothiols, and Neurodegeneration in Different Central Nervous System Demyelinating Disorders: Is There a Relationship?

Fominykh V, Vorobyeva , Onufriev M, Brylev L, Zakharova , Gulyaeva N

BACKGROUND AND PURPOSE: A few groups have suggested that activated cytokines and nitrosative stress are closely involved in the pathogenesis of different demyelinating disorders induced by the neuroinflammatory destruction of...
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Serum Neurofilament Light Chain Levels Are Related to Small Vessel Disease Burden

Duering M, Konieczny , Tiedt S, Baykara E, Tuladhar A, van Leijsen E, Lyrer P, Engelter S, Gesierich , Achmüller M, Barro C, Adam R, Ewers M, Dichgans M, Kuhle J, de Leeuw F, Peters N

BACKGROUND AND PURPOSE: Neurofilament light chain (NfL) is a blood marker for neuroaxonal damage. We assessed the association between serum NfL and cerebral small vessel disease (SVD), which is highly...
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L-plastin: Structure, Regulation, and Roles in Cancer Invasion and in Macrophages

Kim HJ, Lee HH

The cytoskeleton consists of 3 filamentous components: intermediate filaments, microtubules, and actin filaments. Actin filaments continuously assemble and disassemble far out of equilibrium to adapt cells in response to external...
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Differential Expression of Ca²⁺-buffering Protein Calretinin in Cochlear Afferent Fibers: A Possible Link to Vulnerability to Traumatic Noise

Sharma K, Seo YW, Yi E

The synaptic contacts of cochlear afferent fibers (CAFs) with inner hair cells (IHCs) are spatially segregated according to their firing properties. CAFs also exhibit spatially segregated vulnerabilities to noise. The...
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Histological study on the effect of nicotine on adult male guinea pig thin skin

Eltony SA, Ali SS

Tobacco smoking has been identified as an important factor in premature skin aging to detect the histological changes occurred in adult male guinea pig thin skin under the influence of...
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Insights into the Therapeutic Potential of Heparinized Collagen Scaffolds Loading Human Umbilical Cord Mesenchymal Stem Cells and Nerve Growth Factor for the Repair of Recurrent Laryngeal Nerve Injury

Pan Y, Jiao G, Yang J, Guo R, Li J, Wang C

Recurrent laryngeal nerve (RLN) injury can result in unilateral or bilateral vocal cords paralysis, thereby causing a series of complications, such as hoarseness and dyspnea. However, the repair of RLN...
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Lentivirus-mediated microRNA-124 gene-modified bone marrow mesenchymal stem cell transplantation promotes the repair of spinal cord injury in rats

Song JL, Zheng W, Chen W, Qian Y, Ouyang YM, Fan CY

Our study aims to explore the effects of lentivirus-mediated microRNA-124 (miR-124) gene-modified bone marrow mesenchymal stem cell (BMSC) transplantation on the repair of spinal cord injury (SCI) in rats. BMSCs...
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Characterization of mesenchymal cells beneath cornification of the fetal epithelium and epidermis at the face: an immunohistochemical study using human fetal specimens

Kim JH, Jin ZW, Murakami G, Cho BH

Fetal development of the face involves a specific type of cornification in which keratinocytes provide a mass or plug to fill a cavity. The epithelial-mesenchymal interaction was likely to be...
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Phosphorylation and Reorganization of Keratin Networks: Implications for Carcinogenesis and Epithelial Mesenchymal Transition

Kim HJ, Choi WJ, Lee CH

Metastasis is one of hallmarks of cancer and a major cause of cancer death. Combatting metastasis is highly challenging. To overcome these difficulties, researchers have focused on physical properties of...
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Time Course and Characteristics of Astrocyte Activation in the Rat Brain after Injury

Lee HH, Park SC, Choe IS, Kim Y, Ha YS

OBJECTIVE: After injury to the central nervous system (CNS), glial scar tissue is formed in the process of wound healing. This can be is a clinical problem because it interferes...
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Immunohistochemical study on cytokeratin expression on developing tongue in Korean native goats (Capra hircus)

Cho GH, Kim M, Kim CS, Kim GS, Won CK

Cytokeratin (CK) comprises the intermediate filament cytoskeleton of epithelial cells. Patterns of CK expression can be regarded as a specific marker for epithelial differentiation status. The aim of this study...
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12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin 8 Phosphorylation and Reorganization via Expression of Transglutaminase-2

Lee EJ, Park MK, Kim HJ, Kang JH, Kim YR, Kang GJ, Byun HJ, Lee CH

  • KMID: 2170651
  • Biomol Ther.
  • 2014 Mar;22(2):122-128.
The stiffness of cancer cells is attributable to intermediate filaments such as keratin. Perinuclear reorganization via phosphorylation of specific serine residue in keratin is implicated in the deformability of metastatic...
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Imprint Cytology of Soft Tissue Myoepithelioma: A Case Study

Park SJ, Kim AR, Gu MJ, Choi JH, Shin DS

  • KMID: 2277450
  • Korean J Pathol.
  • 2013 Jun;47(3):299-303.
Soft tissue myoepithelioma is a rare neoplasm composed of myoepithelial cells. Here, we describe the cytologic features of soft tissue myoepithelioma arising on the right forearm in an 18-year-old man....
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Spatial relationship between expression of cytokeratin-19 and that of connexin-43 in human fetal kidney

Hieda K, Hayashi S, Kim JH, Murakami G, Cho BH, Matsubara

Connexin-43, a major gap junction protein, and cytokeratin-19, one of the intermediate filament keratins, are known to be markers of well-differentiated epithelium. In this study, we investigated the expression of...
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Expression of carbonic anhydrase IX in human fetal joints, ligaments and tendons: a potential marker of mechanical stress in fetal development?

Kim JH, Parkkila S, Shibata S, Fujimiya M, Murakami G, Cho BH

Carbonic anhydrase type IX (CA9) is known to express in the fetal joint cartilage to maintain pH against hypoxia. Using paraffin-embedded histology of 10 human fetuses at 10-16 weeks of...
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Expression of Desmoglein-1 in Fetal Skin Development

Kim JH, Kim EJ, Park HJ, Joh OJ, Song KY

  • KMID: 2247545
  • Korean J Dermatol.
  • 2011 Sep;49(9):786-794.
BACKGROUND: Desmosomes are cell-cell adhesion complexes that provide mechanical integrity to keratinocytes by linking them to keratin intermediate filaments. Desmosomes are composed of two major transmembrane proteins, desmoglein and desmocollin....
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Expression of Intermediate Filament Proteins in Rat Brain after Cryoinjury

No KT, Hwang KG, Yoo KS

  • KMID: 1468156
  • J Korean Child Neurol Soc.
  • 2009 May;17(1):10-21.
PURPOSE: Traumatic brain injury is a multifaceted injury that involves direct mechanical damage, intraparenchymal and subarachnoid hemorrhage, breakdown of the blood-brain barrier, excitotoxicity, and ischemia. Even though much investigations were...
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Desmoplastic Small Round Cell Tumor with Ovarian Involvement: A Case Report

Lee SH, Kim WS, Kim JH, Han HS, Lim SD, Kim SY, Hwang TS

  • KMID: 2073802
  • Korean J Pathol.
  • 2009 Apr;43(2):185-188.
Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive neoplasm that preferentially involves the abdominal and pelvic cavities in relatively young males. We present a rare case of DSRCT...
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Screening of genes differentially expressed in cultured human periodontal ligament cells and human gingival fibroblasts

Yoon HJ, Choi MH, Yeo SI, Park JW, Choi BJ, Kim MK, Kim JC, Suh JY

  • KMID: 2424991
  • J Korean Acad Periodontol.
  • 2006 Sep;36(3):613-625.
Periodontal ligament(PDL) cells and human gingival fibroblasts(HGFs) play important roles in development, regeneration, normal function, and pathologic alteration. PDL cells and HGFs have the similarity related with general characteristics of...
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Up-regulation of PSD-95 in the Rat Hippocampal Formation after Chronic Renal Failure

Jung YW, Moon IS, Choi DH, Ko BH

  • KMID: 1510195
  • Korean J Anat.
  • 2006 Aug;39(4):289-295.
The mechanism of central nervous system (CNS) dysfunction in uremia are multifactorial and only partially characterized. Studies using hippocampal formation (HF) evaluate the relationship between the uremia and memory impairment. Immunoblots with...
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