Ann Dermatol.  1996 Apr;8(2):153-157. 10.5021/ad.1996.8.2.153.

Malignant Peripheral Nerve Sheath Tumor Arising from Neurofibromatosis

• Ha SJ
• Park YM
• Yi JY
• Kim TY
• Kim CW
• Lee JY
• Kang SJ

• KMID: 2360550
• DOI: http://doi.org/10.5021/ad.1996.8.2.153

Abstract

A 65-year-old woman complained of a pedunculated, huge mass on the anterior chest associated with neurofibromatosis type 1. The clinical and histological data showed the possibility of a malignant peripheral nerve sheath tumor. On electron microscopy, we found the characteristic findings of a malignant peripheral nerve sheath tumor, such as the foci of en-tangled cytoplasmic processes, undifferentiated spindle cells having large pleomorphic nuclei with prominent nucleoli, distinct basal cell lamina, rudimentary cell junctions, intermediate filaments and clumps of glycogen in the tumor cells. We, herein, report a case of malignant peripheral nerve sheath tumor arising from neurofibromatosis, studied by electron microscopy.

Keyword

Electron microscopic study; Malignant peripheral nerve sheath tumor; Neurofibromatosis

MeSH Terms

Aged
Cytoplasm
Female
Glycogen
Humans
Intercellular Junctions
Intermediate Filaments
Microscopy, Electron
Neurofibromatoses*
Neurofibromatosis 1
Peripheral Nerves*
Thorax
Glycogen