Korean J Dermatol.  1996 Feb;34(1):166-170.

A Case of Necrolytic Migratory erythema Induced by a Pancreatic Insufficiency

• Jang MS
• Kim YJ
• Chae YS
• Suh KS
• Kim ST

Abstract

Necrolytic migratory erythema is a cutaneous reaction pattern with specific histopathologic features that is typically associated with a functioning pancreatic islet cell neoplasm such as a glucagonoma. However, cases without. glucagonoma have also been reported, such as, liver cirrhosis, chronic pancreatitis, celiac sprue etc. Other clinical features include anemia, glossitis and weight loss. We report a case of neccrolytic migratory erythema induced by a pancreatic insufficiency without glucagonoma. A 43-year-old male was seen at our department because of rnultiple erythematous, desquamative and erosive patches on the whole body for 1 month. He also had weight loss(25Kg) and stomatitis. Seven years previously he had a Whipple's procedure for a pancreatic head rupture. The laboratory data showed a low protein and zinc level, and high glucagon level. Histopathologic findings of the case showed epidermal edema and pallor, and superficial epiderrnal necrosis. The patient improved progressively after intravenous infusion of amino acids with a pancreatic enzyme supplementation.

Keyword

Necrolytic migratory erythema; Pancreatic insufficiency

MeSH Terms

Adult
Amino Acids
Anemia
Celiac Disease
Edema
Erythema
Exocrine Pancreatic Insufficiency*
Glossitis
Glucagon
Glucagonoma
Head
Humans
Infusions, Intravenous
Islets of Langerhans
Liver Cirrhosis
Male
Necrolytic Migratory Erythema*
Necrosis
Pallor
Pancreatitis, Chronic
Rupture
Stomatitis
Weight Loss
Zinc
Amino Acids
Glucagon
Zinc