Korean J Dermatol.
2005 Jun;43(6):856-859.
A Case of Glucagonoma Syndrome Diagnosed as Necrolytic Migratory Erythema
- Affiliations
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- 1Department of Dermatology, College of Medicine, Kosin University, Busan, Korea. ksderm98@unitel.co.kr
- 2Department of Internal Medcine, College of Medicine, Kosin University, Busan, Korea.
Abstract
- Necrolytic migratory erythema (NME) is a typical cutaneous manifestation of glucagonoma syndrome. The entire syndrome consists of NME, glucose intolerance, weight loss, anemia, glossitis, diarrhea, and increased glucagon levels. We herein report a patient with glucagonoma syndrome who was diagnosed as having NME. A 48-year-old male presented with a 2-month history of painful erythematous, desquamative, erosive papules and plaques on both lower extremities. Histological examination revealed an intraepidermal cleft, the presence of vacuolated, pale epidermal cells, and necrosis in the upper epidermis. His glucagon level was 2650 pg/ml, with the upper limit of a normal range being 250 pg/ml. The patient was treated with octreotide, and showed an improvement of the skin eruption with normalization of the glucagon level within 4 weeks.
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