Korean Circ J.  1981 Dec;11(2):115-122. 10.4070/kcj.1981.11.2.115.

The Effect of Pantethine(Pantomin(R)) on Serum Cholesterol and Triglyceride in Hyperlipidemic Patients

• Choi IG
• Yoon SH
• Kim TH
• Lee BH
• Lee CK

• KMID: 2229769
• DOI: http://doi.org/10.4070/kcj.1981.11.2.115

Abstract

The incidence of atherosclerosis in Korea seems to be much increased due to diet change after national development. The pathogenesis of atherosclerosis is not clarified and there are many hypothesis but the most recent and reliable hypothesis is the ratio of HDL-cholesterol per total cholesterol. Under the basis of this hypothesis there have been much trials to administer the agents which has effect on lipid metabolism, so we tried pantethine on 30 patients who visited Han-Yang University Hospital Internal medicine Department, and the result as follows; 1) The mean age of study population was 50.1 years of age, mean body weight was 62kg, and mean height was 160.8cm. male was 17, and female 10. 2) The associated disease of study population was <19 with> cardiovascular disease, in 19, gastrointestinal disease 3, obesity in 1 and others in 4. 3) The undesirable effect of the drug was found on 3 patients; that is, constipation on 1 patient, dizziness on 1 patient, and skin eruption on 1 patient. 4) The mean serum lipids before and after pantethine administration(levels) are as following table. In conclusion, it seems that the effect of the drug which decreases the serum lipids is mild at initial but more increasing as the time goes by and constant, and we experience little side reaction except mild dizziness, constipation and skin eruption.

MeSH Terms

Atherosclerosis
Body Weight
Cardiovascular Diseases
Cholesterol*
Constipation
Diet
Dizziness
Female
Gastrointestinal Diseases
Humans
Incidence
Internal Medicine
Korea
Lipid Metabolism
Male
Obesity
Skin
Triglycerides*
Cholesterol