Korean J Crit Care Med.  1999 Nov;14(2):132-136.

Effects of Mg2+ Intravenous Pretreatment on Brain Energy Metabolism in Acute Ischemic-Reperfusion Model in Cats: 31P and 1H Magnetic Resonance Spectroscopic Study

• Suk EH
• Kang JY
• Chun SK
• Park PH
• Lim KH
• Lee JH
• Lim TH

Abstract

BACKGOUND: This study was purposed to evaluate the effects of Mg2+ pretreatment on cerebral ischemic injury in cats.
METHODS
Global cerebral ischemia was induced by ligation of both innominate arteries following ligation of inferior vena cava under lowered mean blood pressure for 20 minutes followed by 3 hrs of reperfusion. Ten cats were divided into 2 groups: Group 1 (n=5) is the control group, for group 2 (n=5) (Mg2+ group), the animals were pretreated with 90 mg/kg of Mg2+ intravenously before subjected to ischemia.
RESULTS
Phosphocreatine/inorganic phosphate (Pcr/Pi) and pH decreased after ischemia and did not recovered during reperfusion. And there were no significant differences between the two groups. The ratios of lactate/N-acetyl aspartate (Lac/NAA) and lactate/creatine (Lac/Cr) increased after ischemia and not recovered during reperfusion. But the ratios were higher for the group 2 than the group 1 during reperfusion (p<0.05). For the Mg2+ group, blood pressure during reperfusion was lower than the control group.
CONCLUSIONS
Mg2+ intravenous pretreatment had no protective effect on this global cerebral ischemia animal model. Even it deteriorated brain energy metabolism by lowering blood pressure.

Keyword

Brain; ischemia; metabolism; Pharmacology; Mg2+

MeSH Terms

Animals
Aspartic Acid
Blood Pressure
Brachiocephalic Trunk
Brain Ischemia
Brain*
Cats*
Energy Metabolism*
Hydrogen-Ion Concentration
Ischemia
Ligation
Metabolism
Models, Animal
Pharmacology
Reperfusion
Vena Cava, Inferior
Aspartic Acid