Korean J Crit Care Med.  2014 May;29(2):59-63. 10.4266/kjccm.2014.29.2.59.

Severe Fever with Thrombocytopenia Syndrome

• Yoo SJ
• Heo ST
• Lee KH

• KMID: 2227762
• DOI: http://doi.org/10.4266/kjccm.2014.29.2.59

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease, caused by a novel species of Phlebovirus of Bunyaviridae family, in China, South Korea, and Japan. SFTS is primarily known as a tick-borne disease, and human-to-human transmission is also possible in contact with infectious blood. Common clinical manifestations include fever, thrombocytopenia, and leukopenia as initial symptoms, and multiple organ dysfunction and failure manifest with disease progression. Whereas disease mortality is reported to be 12% to 30% in China, a recent report of cumulative SFTS cases indicated 47% in Korea. Risk factors associated with SFTS were age, presence of neurologic disturbance, serum enzyme levels, and elevated concentrations of certain cytokines. Diagnosis of SFTS is based on viral isolation, viral identification by polymerase chain reaction, and serologic identification of specific immunoglobulin G. Therapeutic guideline has not been formulated, but conservative management is the mainstream of treatment to prevent disease progression and fatal complications.

Keyword

phlebovirus; severe fever with thrombocytopenia syndrome; Korea

MeSH Terms

Bunyaviridae
China
Communicable Diseases, Emerging
Cytokines
Diagnosis
Disease Progression
Fever*
Humans
Immunoglobulin G
Japan
Korea
Leukopenia
Mortality
Phlebovirus
Polymerase Chain Reaction
Risk Factors
Thrombocytopenia*
Tick-Borne Diseases
Cytokines
Immunoglobulin G