J Rheum Dis.  2011 Mar;18(1):64-67. 10.4078/jrd.2011.18.1.64.

Eosinophilic Fasciitis as the Initial Manifestation of Graft-Versus-Host Disease

• Yoo IS
• Kim MK
• Song ST
• Kim JH
• Kim JM
• Jo DY
• Kang SW

• KMID: 2223186
• DOI: http://doi.org/10.4078/jrd.2011.18.1.64

Abstract

Eosinophilic fasciitis (EF) is a relatively rare disorder characterized by eosinophilia of the peripheral blood and inflammation of fascia and skin. The etiology of EF is unknown but it can precede or occur concomitantly with hematologic disorders including malignancy. EF can rarely occur after bone marrow transplantation and is a feature of chronic graft-versus-host disease (cGVHD). We report a 49-year-old man who developed EF as the first manifestation of cGVHD after allogeneic hematopoietic stem cell transplantation (AlloHSCT).

Keyword

Eosinophilic fasciitis; Graft-versus-host disease; Allogeneic hematopoietic stem cell transplantation

MeSH Terms

Bone Marrow Transplantation
Eosinophilia
Eosinophils
Fascia
Fasciitis
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Inflammation
Middle Aged
Skin
Eosinophilia
Fasciitis

Figure

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  Figure 1. Induration and swelling of both forearm and wrist (arrow).

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  Figure 2. Forearm skin & muscle biopsy. Numerous eosinophils (arrow) and mononuclear cells were observed in fascia and muscle.

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  Figure 3. Buttock skin biopsy. Vacuolar degeneration of basal cells, dermal melanophages, sparse infiltration of perivascular mononuclear cell and eosinophils.

Reference

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