J Rheum Dis.  2011 Mar;18(1):60-63. 10.4078/jrd.2011.18.1.60.

A Case of Klinefelter's Syndrome Associated with Rheumatoid Arthritis

• Mo SI
• Lee HG
• Cho AR
• Chung HK
• Kim KW
• Lee HM
• Kang BI
• Ko GB
• Lee SW
• Nah SS

• KMID: 2223185
• DOI: http://doi.org/10.4078/jrd.2011.18.1.60

Abstract

Klinefelter's syndrome (KFS) is a gonosomal aberration disease that occurs in males, and is characterized by 47, XXY karyotype, hypogonadism and a lack of secondary sexual characteristics. A potential link between this hormonally deficient syndrome and autoimmune disease, particularly systemic lupus erythematosus (SLE), has been reported. On the other hand, KFS is rarely reported to be accompanied by rheumatoid arthritis (RA), and there are no Korean cases reported. We report the first Korean case of a KFS patient with sero-positive RA and discuss the role of the pathogenesis of RA with KFS.

Keyword

Klinefelter's syndrome; Rheumatoid arthritis; X chromosome

MeSH Terms

Aluminum Hydroxide
Arthritis, Rheumatoid
Autoimmune Diseases
Carbonates
Hand
Humans
Hypogonadism
Karyotype
Klinefelter Syndrome
Lupus Erythematosus, Systemic
Male
X Chromosome
Aluminum Hydroxide
Carbonates

Reference

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