Korean Diabetes J.  2008 Apr;32(2):149-156. 10.4093/kdj.2008.32.2.149.

Association of Adiponectin and Hepatic Steatosis in Adults with Normal Transaminase Levels

• Mun JH
• Lee SE
• Ahn JH
• Shinn SH

• KMID: 2222511
• DOI: http://doi.org/10.4093/kdj.2008.32.2.149

Abstract

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndrome including insulin resistance, hypertension, dyslipidemia, central obesity, type 2 diabetes, and cardiovascular disease. In NAFLD, insulin resistance plays an important role in the progression of liver damage. In this study, we evaluated insulin resistance, plasma adiponectin, hepatic steatosis, and their association in adults with normal liver transaminase concentrations.
METHODS
We analyzed 111 subjects, aged over 20 years old, who visited the Health Management Center at Chung-Ang University Hospital between May 2006 and August 2006. They had neither history nor clinical evidence of diabetes, cardiovascular or liver disease. They were divided into three groups by the degree of hepatic steatosis based on ultrasound findings. Anthropometric parameters were measured and blood samples were drawn after eight hours of fasting.
RESULTS
Hepatic steatosis had a positive correlation with body mass index, waist circumference, blood pressure, triglycerides, HOMA-IR, and QUICKI. Moreover, it had a negative correlation with high-density lipoprotein cholesterol and adiponectin. Triglycerides, Adiponectin, and QUICKI were independent variables in predicting the degree of hepatic steatosis.
CONCLUSION
This finding suggests that triglycerides and plasma adiponectin are independent predictors of hepatic steatosis in adults with normal liver transaminase concentrations.

Keyword

Adiponectin; Insulin resistance; Non-alcoholic fatty liver disease

MeSH Terms

Adiponectin
Adult
Aged
Blood Pressure
Body Mass Index
Cardiovascular Diseases
Cholesterol
Dyslipidemias
Fatty Liver
Humans
Hypertension
Insulin Resistance
Lipoproteins
Liver
Liver Diseases
Obesity, Abdominal
Plasma
Triglycerides
Waist Circumference
Adiponectin
Cholesterol
Fatty Liver
Lipoproteins
Triglycerides

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