Allergy Asthma Respir Dis.  2015 Nov;3(6):439-445. 10.4168/aard.2015.3.6.439.

Fractional exhaled nitric oxide in Korean children with allergic rhinitis

Affiliations
  • 1Department of Pediatrics, Inha University School of Medicine, Incheon, Korea. kimjhmd@inha.ac.kr
  • 2Environmental Health Center for Allergic Rhinitis, Inha University Hospital, Incheon, Korea.

Abstract

PURPOSE
Fractional exhaled nitric oxide (FeNO) is useful for the diagnosis of allergic rhinitis (AR) as well as bronchial asthma (BA). However, FeNO may differ according to race, age, and other determinants. There have been few studies about FeNO in Korean children with AR. The aims of this study were to evaluate the value of FeNO in AR and to compare FeNO, and determinants of FeNO levels between AR, BA, and combined AR and BA.
METHODS
This study included 647 children aged 5 to 17. The children were classified into 5 groups after performing the skin test, FeNO measurement, the pulmonary function test, and the methacholine challenge test: those with nonallergic rhinitis (NAR), those with AR, those with BA, and those with combined AR and BA, and healthy controls,.
RESULTS
The values of FEV1 (forced expiratory volume in one second) %predicted were 94.4%+/-12.6%, 93.8%+/-20.7%, 90.0%+/-17.4% in AR, BA, and combined AR and BA, respectively. The values of FeNO in AR (32.3+/-25.0 ppb), BA (31.1+/-20.5 ppb), and combined AR and BA (34.5+/-30.4 ppb) were significantly higher compared to those of NAR (16.8+/-13.5 ppb) and controls (15.9+/-12.5 ppb). There was no significant difference in FeNO among AR, BA, and combined AR and BA. FeNO was significantly higher in patients with > or =4 positive results (36.6+/-29.2 ppb) than in those with <4 positive skin test results (27.6+/-20.7 ppb). When the receiver operating characteristic curve analysis for prediction of AR showed 0.756 of area under the curve, the cutoff level of FeNO was 16 ppb.
CONCLUSION
In this study, children with AR had increased levels of FeNO. It is suggested that AR may have eosinophilic bronchial inflammation without BHR or clinical asthma.

Keyword

Allergic rhinitis; Nonallergic rhinitis; FeNO; Eosinophilic inflammation

MeSH Terms

Asthma
Child*
Continental Population Groups
Diagnosis
Eosinophils
Humans
Inflammation
Methacholine Chloride
Nitric Oxide*
Respiratory Function Tests
Rhinitis*
ROC Curve
Skin Tests
Methacholine Chloride
Nitric Oxide

Figure

  • Fig. 1 Receiver operating characteristic curve analysis for prediction of allergic rhinitis among rhinitis patient. FeNO, fractional exhaled nitric oxide.


Cited by  2 articles

Clinical application of fractional exhaled nitric oxide in pediatric allergic rhinitis
Doo Hee Han
Allergy Asthma Respir Dis. 2015;3(6):385-386.    doi: 10.4168/aard.2015.3.6.385.

Clinical characteristics of allergic rhinitis and nonallergic rhinitis in Korean children
Na Hae Won, Sang Hyun Park, So Hyun Ahn, Chae Bong Kim, Jung Hyun Kwon, Won Hee Seo, Dae Jin Song, Young Yoo
Allergy Asthma Respir Dis. 2020;8(1):20-29.    doi: 10.4168/aard.2020.8.1.20.


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