Allergy Asthma Respir Dis.  2015 Nov;3(6):410-416. 10.4168/aard.2015.3.6.410.

Clinical characteristics of respiratory viral infection in children during spring/summer: focus on human bocavirus

Affiliations
  • 1Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea. joung756@dsmc.or.kr
  • 2Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea.

Abstract

PURPOSE
We evaluated the clinical characteristics of respiratory viruses that were frequently found in children during spring/summer, namely, human bocavirus (hBoV), human metapneumovirus (hMPV), parainfluenza virus (PIV), and human rhinovirus (hRV).
METHODS
This study enrolled patients with acute lower respiratory infection in whom respiratory virus reverse transcriptase polymerase chain reaction was performed between March 2013 and August of 2013. We retrospectively reviewed the medical records to collect the patients' data.
RESULTS
A total of 96 patients were enrolled and divided into 5 categories: hBoV in 19 patients (19.8%), hMPV in 18 patients (18.8%), PIV in 16 patients (16.7%), hRV in 20 patients (20.8%), and negative result in 23 patients (24.0%). The mean age of the patients was 8.2+/-5.9 months (median, 7.5 months; range, 1-24 months), and the male-to-female ratio was 1.1:1. The most common diagnoses were acute bronchiolitis (62.5%) and pneumonia (30.2%). Compared to other patients, those with hBoV were older (12.3+/-4.9 months, P=0.001) and more frequently diagnosed with acute bronchiolitis (P=0.005). In addition, they showed higher incidences of tachypnea and rales (P=0.039 and P=0.035, respectively), and were more frequently treated with oxygen and systemic steroids (P=0.044 and P=0.001, respectively) than the other patients.
CONCLUSION
We compared respiratory viruses in children during spring/summer and found that hBoV may have more severe clinical manifestations than other viruses.

Keyword

Respiratory infection; Human bocavirus; Child

MeSH Terms

Bronchiolitis
Child*
Diagnosis
Human bocavirus*
Humans
Humans*
Incidence
Medical Records
Metapneumovirus
Oxygen
Paramyxoviridae Infections
Pneumonia
Respiratory Sounds
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Rhinovirus
Steroids
Tachypnea
Oxygen
Steroids

Figure

  • Fig. 1 Diagnosis of the patients according to causing virus. The most common clinical diagnosis was acute bronchiolitis, and the other diagnoses were pneumonia, bronchitis and croup. hBoV, human bocavirus; hMPV, human metapneumonvirus; PIV, parainfluenza virus; hRV, human rhinovirus.

  • Fig. 2 Age (A) and gender (B) of the patients with human bocavirus (hBoV) and the others. The patients with human bocavirus were older than other patients (P=0.001) (A), but there was no gender difference (B).

  • Fig. 3 The percentage of the patients with human bocavirus (hBoV) and the other patients according to clinical manifestations. The patients with human bocavirus showed more incidence of tachypnea and rale than other patients (P=0.039, P=0.035).

  • Fig. 4 The percentage of the patients with human bocavirus (hBoV) and the other patients according to management. The patients with human bocavirus were more commonly treated with oxygen and systemic steroid than other patients (P=0.044, P=0.001).


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