Allergy Asthma Respir Dis.  2016 Jan;4(1):44-48. 10.4168/aard.2016.4.1.44.

Vitamin D serum levels and risk of asthma in children

• You MJ
• Kim WK

• KMID: 2218618
• DOI: http://doi.org/10.4168/aard.2016.4.1.44

Abstract

PURPOSE
The role of vitamin D in traditional atopic disorders (i.e., asthma, allergic rhinitis, and atopic dermatitis) is still uncertain. We have analyzed the association between serum 25-hydroxyvitamin D3 (25(OH)-D3) levels and asthma in children.
METHODS
A total of 133 children were enrolled between April 2008 and December of 2008. Children were divided into 3 groups: the asthma group (n=80), bronchiolitis group (n=50), and normal group (n=35). Serum samples were collected and checked for 25(OH)-D3 levels. From the blood samples, we measured eosinophil counts, total IgE, specific IgE (Dermatophagoides pteronyssinus, Dermatophagoides farinae, milk, egg, cat, dog, cockroach) (Uni-CAP FEIA system).
RESULTS
The mean age of the patients was 4.6 years. The mean 25(OH)-D3 levels of the asthma, bronchiolitis, and normal groups were 17.2+/-8.9, 22.5+/-9.3, and 27.8+/-10.2 ng/mL, respectively (P<0.01). There was no association between allergens and vitamin D levels. Mean 25(OH)-D3 levels were lower at acute state of asthma than at stable state.
CONCLUSION
The mean level of 25(OH)-D3 was associated with asthma and acute state of asthma. Further experimental and clinical studies are needed to establish a definite link between vitamin D levels and asthma.

Keyword

Vitamin D; Asthma; Bronchiolitis

MeSH Terms

Allergens
Animals
Asthma*
Bronchiolitis
Calcifediol
Cats
Child*
Dermatophagoides pteronyssinus
Dogs
Eosinophils
Humans
Immunoglobulin E
Milk
Ovum
Rhinitis
Vitamin D*
Vitamins*
Allergens
Calcifediol
Immunoglobulin E
Vitamin D
Vitamins

Figure

• 

  Fig. 1 The box plot of serum vitamin D levels in asthma states. 25(OH)-D3, 25-hydroxyvitamin D3.

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