J Korean Pediatr Soc.  2000 Nov;43(11):1430-1439.

Effects of Partical Liquid Ventilation on Gas Exchange, Hemodynamics, and Pulmonary Function in Newborn Piglet with Resipratory Distress

• Chang YS
• Park WS

Abstract

PURPOSE: To evaluate gas exchange, hemodynarnics and pulmonary function during partial liquid ventilation(PLV) using PFC(perfluorodecalin), compared with conventional gas ventilation in newborn piglets with saline lavage-induced respiratory distress.
METHODS
In a total of 16 instrumented and ventilated piglets, acute respiratory distress(below 70 mmHg of PaOz at FiOz 1.0) was induced by repeated saline pulmonary lavage. The piglets were randomized to receive either gas ventilation only(control group, n=8) or PLV(PLV group, n=8) by 3 consecutive intratracheal instillations of 10mL/kg of perfluorodecalin at lavage baseline and at 30, 60min after lavage. All animals were mechanically ventilated for 150min after lavage with time-cycled pressure-limited gas ventilation, a peak inspiratory pressure of 30cm HO, frequency of 30breaths/min, FiO;, 1.0 and a positive end-expiratory pressure of 4cm HzO. All measurements were made at 30inin interval afterwards to 150rnin after lavage.
RESULTS
All animals developed severe hypoxemia, hypercarbia, and acidosis due to increased transpulmonary shunt fraction after saline lavage, which persisted during the experiments in control group. PaOz significantly increased with increases in dosage of PFC from 56+/-6 to 235+/-90 mmHg and PaCOz also significantly decreased in the PLV group. Venous admixture and pH showed significant differences between the two groups. Pulmonary dynamic cornpliance, tidal volume and mean airway resistance were also significantly improved in the PLV group. However, hemodynamic parameters were similar in both groups.
CONCLUSION
PLV with perfluorodecalin irnproves gas exchange and pulmonary function in newborn piglets with saline lavage-induced respiratory distress.

Keyword

Partial liquid ventilation; Perfluorodecaline; Respiratory distress; Gas exchange; Pul-rnonary' function; Hemodynamics; Piglet

MeSH Terms

Acidosis
Airway Resistance
Animals
Anoxia
Hemodynamics*
Humans
Hydrogen-Ion Concentration
Infant, Newborn*
Liquid Ventilation*
Positive-Pressure Respiration
Therapeutic Irrigation
Tidal Volume
Ventilation