Korean J Anesthesiol.  2009 Aug;57(2):203-209. 10.4097/kjae.2009.57.2.203.

The effects of inspiratory to expiratory ratio on ventilation and oxygenation during high frequency partial liquid ventilation in a rabbit model of acute lung injury

• Song MH
• Choi IC
• Hahm KD
• Jeong YB
• Choi KT

• KMID: 2238091
• DOI: http://doi.org/10.4097/kjae.2009.57.2.203

Abstract

BACKGROUND
We examined the effects of varying inspiratory to expiratory (I : E) ratio on gas exchange and hemodynamics during high frequency partial liquid ventilation (HFPLV), a combination of high frequency ventilation (HFV) and partial liquid ventilation (PLV), in a rabbit model of acute lung injury. METHODS: Twelve rabbits treated with repeated saline lavage were divided into two groups. In the HFPL group (n = 6), 6 ml/kg of perfluorodecaline was administered through the endotracheal tube. Rabbits in this group and in the HFJ group (n = 6) were treated with high frequency jet ventilation (HFJV) at I : E ratios of 1 : 1, 1 : 2, and 1 : 3 for 15 minutes, and arterial blood gas, mixed venous blood gas and hemodynamic parameters were measured. RESULTS: We observed no significant respiratory and hemodynamic differences between the two groups. At an I : E ratio of 1 : 1, the PaO2 was significantly higher, and the shunt rate and PaCO2 were significantly lower in both groups, compared with I : E ratios of 1 : 2 and 1 : 3. Cardiac output at the 1 : 3 I : E ratio was significantly higher than at 1 : 1. CONCLUSIONS: These findings indicate that, in this model, a 1 : 1 I : E ratio was superior for oxygenation and ventilation than I : E ratios of 1 : 2 or 1 : 3, while having no detrimental effects on hemodynamics.

Keyword

Acute lung injury; Expiratory ratio; Gas exchange; High frequency jet ventilation; Inspiratory; Partial liquid ventilation; Perfluorocarbon

MeSH Terms

Acute Lung Injury
Cardiac Output
Hemodynamics
High-Frequency Jet Ventilation
High-Frequency Ventilation
Liquid Ventilation
Oxygen
Rabbits
Therapeutic Irrigation
Ventilation
Oxygen