Korean J Anesthesiol.  2012 Oct;63(4):346-352. 10.4097/kjae.2012.63.4.346.

The effect of positive-end expiratory pressure on oxygenation during high frequency jet ventilation and conventional mechanical ventilation in the rabbit model of acute lung injury

• Bang JO
• Ha SI
• Choi IC

• KMID: 1767174
• DOI: http://doi.org/10.4097/kjae.2012.63.4.346

Abstract

BACKGROUND
The use of positive end expiratory pressure (PEEP) in patients with acute lung injury (ALI) improves arterial oxygenation by alleviating pulmonary shunting, helping the respiratory muscles to decrease the work of breathing, decreasing the rate of infiltrated and atelectatic tissues, and increasing functional residual capacity. In a rabbit model of saline lavage-induced ALI, we examined the effects of PEEP on gas exchange, hemodynamics, and oxygenation during high frequency jet ventilation (HFJV), and then compared these parameters with those during conventional mechanical ventilation (CMV).
METHODS
Twelve rabbits underwent repeated saline lavage to create ALI. The animals were divided in 2 groups: 1) Group CMV (n = 6), and 2) Group HFJV (n = 6). In both groups, we applied 2 levels of PEEP (5 cmH2O and 10 cmH2O) and then measured the arterial blood gas, mixed venous blood gas, and hemodynamic parameters.
RESULTS
With administration of PEEP of either 5 cmH2O or 10 cmH2O, the arterial oxygen content of both groups was increased, although without statistically significant differences between groups. On the contrary, the arterial carbon dioxide content was significantly decreased in the HFJV group, as compared with the CMV group, during the entire experiment. Furthermore, there was significant decreases in mean arterial pressures in both groups with a PEEP of 10 cmH2O.
CONCLUSIONS
The application of PEEP in rabbits with ALI effectively improves oxygenation in either HFJV or CMV.

Keyword

Acute lung injury; High frequency jet ventilation; Positive-end expiratory pressure

MeSH Terms

Acute Lung Injury
Animals
Arterial Pressure
Carbon Dioxide
Functional Residual Capacity
Hemodynamics
High-Frequency Jet Ventilation
Humans
Oxygen
Positive-Pressure Respiration
Rabbits
Respiration, Artificial
Respiratory Muscles
Therapeutic Irrigation
Work of Breathing
Carbon Dioxide
Oxygen