J Korean Pediatr Soc.
2002 Dec;45(12):1591-1595.
Familial Adenomatous Polyposis Improved by COX-2 Inhibitor in a Child
- Affiliations
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- 1Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea. bhchoi@knu.ac.kr
- 2Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea.
Abstract
- Familial adenomatous polyposis(FAP) is an autosomal dominant disease characterized by numerous adenomas in the colorectum. Patients with FAP are always at risk of malignant transformation, so that colectomy is unavoidable. NSAID, such as sulindac, and selective COX-2 inhibitor, such as celecoxib, have shown a positive effect on FAP by causing polyp regression in some patients. We report a case of FAP in a 9-year-old female whose polyposis regressed markedly after six months-treatment with celecoxib.
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