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A single nonsteroidal anti-inflammatory drugs-induced anaphylaxis to diclofenac confirmed by skin testing

Lee J

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a major culprit of drug-induced hypersensitivity. No reliable diagnostic tests other than a direct challenge are available. Cross-reactivity among NSAIDs that inhibit cyclooxygenase-1 is common....
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Update on the Management of Nonsteroidal Anti-Inflammatory Drug Hypersensitivity

Yeung WY, Park HS

The clinical phenotypes of nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity are heterogeneous with various presentations including time of symptom onset, organ involvements, and underlying pathophysiology. Having a correct diagnosis can be...
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Complementary Participation of Genetics and Epigenetics in Development of NSAID-exacerbated Respiratory Disease

Lee JU, Park JS, Chang HS, Park CS

Nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) has attracted a great deal of attention because of its association with severe asthma. However, it remains widely underdiagnosed in asthmatics as well...
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Bleeding after Taking Dual Antiplatelets and NSAID Concurrently

Seo J, Choi J, Son P, Lee S, Chae H, Kang G, Ji E

When stenting is applied to treat myocardial infarction, antiplatelet agents are administered to prevent thrombosis, which increases the risk of bleeding. Patients with myocardial infarction are also more likely to...
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Comparison of 1% Prednisolone and 0.1% Bromfenac Solutions for Preventing Macular Edema after Cataract Surgery

Jeong HK, Shin WB, Seo KY, Lee J

PURPOSE: To compare the clinical effectiveness of 1% Prednisolone acetate ophthalmic solution and 0.1% Bromfenac sodium hydrate ophthalmic solution on prevention of cystoid macular edema after cataract surgery. METHODS: A retrospective...
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Seven Steps to the Diagnosis of NSAIDs Hypersensitivity: How to Apply a New Classification in Real Practice?

Kowalski M, Makowska J

Frequent use of non-steroidal anti-inflammatory drugs (NSAIDs) has been paralleled by increasing occurrence of adverse reactions, which vary from mild local skin rashes or gastric irritation to severe, generalized symptoms...
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A Case of Ischemic Colitis Related with Usual Dosage of Ibuprofen in a Young Man

Kim EJ, Park MI, Park SJ, Moon W, Yeo GE, Lee WH

Ischemic colitis is a medical condition in which inflammation and injury of the large intestine result from inadequate blood supply. Although uncommon in the general population, ischemic colitis occurs with...
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Non-Helicobacter pylori, Non-NSAID Peptic Ulcer Disease

Rew JS

  • KMID: 2269330
  • Korean J Med.
  • 2014 Jun;86(6):678-685.
Non-Helicobacter pylori, non-NSAID peptic ulcer disease, termed idiopathic peptic ulcer disease (IPUD), is being increasingly recognized. Current data suggest that the relative proportion of patients with IPUD among those with...
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Endoscopic Hemostasis for Bleeding Gastric Ulcer Caused by Ibuprofen in a 16-month-old Infant

Na SY

  • KMID: 2315328
  • Pediatr Gastroenterol Hepatol Nutr.
  • 2012 Jun;15(2):105-110.
Gastric ulcers are rare in children and are typically seen in cases of Helicobacter pylori (H. pylori) infection, non-steroidal anti-inflammatory drugs (NSAIDs) use, and critical illnesses such as sepsis. The...
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Renal Infarction after NSAID Treatment

Yoon SH, Kim YL, Park SH, Kim CD, Choi JY, Yun SR

  • KMID: 2263564
  • Korean J Med.
  • 2012 May;82(5):618-622.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are popular in general practice. Their adverse renal effects have been well documented. Common NSAID-related renal side effects range from dysfunctional renal hemodynamic responses, nephrotic syndrome,...
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Comparison of Effectiveness and Safety of Tramadol/Acetaminophen and Non-steroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Knee Osteoarthritis in Elderly Patients

Kim SY, Ryou JW, Hur JW

OBJECTIVE: To compare the analgesic effectiveness and safety of tramadol 37.5 mg/acetaminophen 325 mg combination tablets (tramadol/acetaminophen) with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of osteoarthrits in elderly patients. METHODS:...
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Gastrointestinal Risk Assessment in the Patients Taking Nonsteroidal Anti-inflammarory Drugs for Lumbar Spinal Disease

Lee BH, Shin BJ, Kim DJ, Lee JC, Suk KS, Park YS, Kim KW, Cho KJ, Shin KY, Koh MS, Moon SH

STUDY DESIGN: A cross-section observational study. OBJECTIVES: To evaluate the current prescription patterns of non-steroidal anti-inflammatory drugs (NSAIDs) and gastrointestinal (GI) risk assessment in patients with lumbar spine disease. SUMMARY OF LITERATURE...
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Gene Expression Analysis of the Human Astrocytoma Cell after Abeta25-35 Stimulation Followed by Ibuprofen Administration

Choi Y, Eun J, Nam S, Kim S

  • KMID: 2339336
  • J Korean Geriatr Soc.
  • 2011 Sep;15(3):144-161.
BACKGROUND: The molecular events leading to the development of sporadic late-onset Alzheimer's disease (AD) have not been defined. A number of mechanism for the protective effects of non-steroidal anti-inflammatory drugs...
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Prevention of NSAID-Associated Gastroduodenal Injury in Healthy Volunteers-A Randomized, Double-Blind, Multicenter Study Comparing DA-9601 with Misoprostol

Lee KN, Lee OY, Choi MG, Choi SR, Lee DH, Lee YC, Kim TN, Choi SC, Rew JS, Seol SY

In addition to inhibiting cyclooxygenase and prostaglandin, nonsteroidal anti-inflammatory drugs (NSAIDs) may cause gastroduodenal injuries due to reactive oxygen species produced by recruited inflammatory cells. DA-9601 is a novel antioxidant...
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Comparison of the Effects of Prophylactic Nonsteroidal Anti-inflammatory Drugs on Macular Edema After Cataract Surgery

Chun BY, Kang SY, Song JS, Kim HM

PURPOSE: To evaluate and compare the efficacy of prophylactic administration of topical nonsteroidal anti-inflammatory (NSAID) drugs on macular edema (ME) following cataract surgery. METHODS: The present open-label non-masked randomized (random number...
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Diclofenac, a Non-steroidal Anti-inflammatory Drug, Inhibits L-type Ca2+ Channels in Neonatal Rat Ventricular Cardiomyocytes

Yarishkin , Hwang EM, Kim D, Yoo JC, Kang SS, Kim DR, Shin JH, Chung HJ, Jeong HS, Kang D, Han J, Park JY, Hong SG

A non-steroidal anti-inflammatory drug (NSAID) has many adverse effects including cardiovascular (CV) risk. Diclofenac among the nonselective NSAIDs has the highest CV risk such as congestive heart failure, which resulted...
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The Use of COX-2 Selective Nonsteroidal Anti-inflammatory Drugs for the Treatment of Osteoarthritis

Song YJ, Ha CW

  • KMID: 2182677
  • J Korean Knee Soc.
  • 2009 Jun;21(2):84-92.
Nonsteroidal anti-inflammatory drugs (NSAIDs), are characterized by their anti-inflammatory, analgesic, and antipyretic activities; they have been widely used for the management of acute pain and chronic inflammation. The mechanism of...
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Safety and efficacy of piroxicam patches for treating knee osteoarthritis

Park SH, Park CY, Kim SK, Kim CG, Choe JY, Shin IH

  • KMID: 2305849
  • Korean J Med.
  • 2008 May;74(5):537-545.
BACKGROUND/AIMS: We wanted to compare the efficacy and safety of a Murupe(R) patch, which is a newly-developed piroxicam patch, with the Trast(R) patch for the treatment of knee osteoarthritis. METHODS: Two...
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Clinical Features of Adverse Drug Reactions in a Tertiary Care Hospital in Korea

  • KMID: 2234478
  • Korean J Asthma Allergy Clin Immunol.
  • 2008 Mar;28(1):35-39.
BACKGROUND: Clinical features of adverse drug reactions (ADR) are different and the incidence is increasing. However, there have been only a few data on the clinical features of ADR in...
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Effects of various NSAIDs on prostaglandin synthesis and cellular configuration of human periodontal ligament cells

Kim HS, Shim HY, Chae CH, Chang YI, Park JW

  • KMID: 2005268
  • J Korean Assoc Oral Maxillofac Surg.
  • 2007 Oct;33(5):455-463.
The present study was designed to evaluate effects of the commonly used NSAIDs(acetaminophen, aspirin, and ibuprofen) on human periodontal ligament cells. Human periodontal ligament cells were grown from a cell...
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