J Korean Soc Magn Reson Med.  1998 Jun;2(1):89-95.

Metabolic Abnormalities in Patients with Mitochondrial Myopathy Evaluated by In Vivo 31P Magnetic Resonance Spectroscopy

• Choe BY
• Park JW
• Hahn SR
• Kim YI
• Lee KS
• Jee WH
• Choi SE
• Lee HK
• Suh TS
• Lee HK
• Shinn KS

Abstract

PURPOSE
To investigate the phosphorus metabolic abnormalities in skeletal muscle of patients with mitochondrial myopathy using in vivo 31P magnetic resonance spectroscopy(MRS). MATERIAL AND METHODS: Patients with mitochondrial myopathy(N=10) and normal control subjects (N=10) participated. All in vivo 31P MRS examinations were performed on 1.5T whole-body MRI/MRS system by using an image selected in vivo spectroscopy (ISIS) pulse sequence that provided a 4 X 4 X 4 cm3 volume of interest (VOI) in the right thigh muscle tissue. Peak areas for each phophorus methabolite were measured using a Marquart algorithm.
RESULTS
The specific features in patients with mitochondrial myopathy were a significant increase of Pi/PCr ratio (p=0.003) and a significant decrease of ATP/PCr ratio (p=0.004) as compared with normal controls. In particular, the beta-ATP/PCr ratio between controls and patients with mitochondrial myopathy was predominantly altered.
CONCLUSIONS
In vivo 31P MRS may be a useful modality in the clinical evaluation of patients with mitochondrial myopathy based on ATP/PCr and Pi/PCr ratios in skeletal muscle tissue and provides a valuable information in further understanding disorders of muscle metabolism.

Keyword

31P magnetic resonance spectroscopy; Mitochondrial myopathy

MeSH Terms

Humans
Magnetic Resonance Spectroscopy*
Metabolism
Mitochondrial Myopathies*
Muscle, Skeletal
Phosphorus
Spectrum Analysis
Thigh
Phosphorus