J Korean Radiol Soc.  1998 Dec;39(6):1171-1176. 10.3348/jkrs.1998.39.6.1171.

In Vivo 31P Magnetic Resonance Spectroscopy in Liver Cirrhosis: Assessment of Phosphorus Metabolites accordingto Hepatic Dysfunction

• Yoon KH
• Lee MG
• Lee JH
• Kim CG
• Auh YH

• KMID: 2201088
• DOI: http://doi.org/10.3348/jkrs.1998.39.6.1171

Abstract

PURPOSE: To assess the spectral alteration of phosphorus metabolities in patients with liver cirrhosis andcompare energy metabolites with clinical grades using 31P MR spectra localized by two-dimensional chemical shiftimaging.
MATERIALS AND METHODS
In 15 normal (control) subjects and 12 patients with liver cirrhosis, 31P MRspectroscopy was undertaken. Patients were divided into two groups, namely 'mild cirrhosis' (Child A, n=5) and'severe cirrhosis' (Child B and C, n=7) according to disease severity, as assessed by Child-Hugh's classification.In vivo 31P MR spectroscopy was performed on a 1.5-T system (Magnetom Vision; Erlangen, Germany), using a surfacecoil. Peak areas of phosphomonoester (PME), inorganic phosphate (Pi), phosphodiester (PDE), and gamma-, alpha- andbeta-ATP were defined. Peak areas of phosphorous metabolites in the spectra were expressed as values of PME/beta-ATP,PDE/beta-ATP, PME/ATP, and PME/PDE.
RESULTS
The values of PME/beta-ATP, PDE/beta-ATP, PME/ATP, and PME/PDE betweencontrol subjects and patients with liver cirrhosis were significantly different. With impaired hepaticdysfunction, PME increased as PDE decreased. In patients with severe cirrhosis, the values of PME/(-ATP andPME/ATP were significantly higher than those of patients with mild cirrhosis.
CONCLUSION
In patients with livercirrhosis, peak areas of PME, were significantly higher, and this might reflect the severity of hepaticdysfunction. PME/(-ATP and PME/ATP valves appear predict the severity of cirrhosis.

Keyword

Liver, cirrhosis; Liver, MR; Magnetic resonance (MR), spectroscopy

MeSH Terms

Fibrosis
Humans
Liver Cirrhosis*
Liver*
Magnetic Resonance Spectroscopy*
Phosphorus*
Phosphorus