J Korean Soc Plast Reconstr Surg.  2004 Sep;31(5):701-706.

Effect of Retinoic Acid Derivatives Using Polyethylene Glycol(PEG), Polyvinyl Pyrrolidone(PVP) on Dermal Wound Healing

• Jung WS
• Cha JH
• Kim YW
• Kim HJ

Abstract

Retinoids are compounds with pleiotropic functions, selectively targeting certain skin structures. They are vitamins which must be derived from diet because retinol(vitamin A) is not synthesized in the body, and also they are hormones with intracrine activity, because retinol is transformed into molecules that bind to nuclear receptors, exhibit their activity, and are subsequently inactivated. Enhanced healing of full-thickness skin wounds has been demonstrated in early wound healing studies. OBJECTIVE: Our purpose is to observe the chemical and histologic effects of topical retinoid derivatives(0.05%) applied directly to the dermal wound of guinea pig. METHODS: We prepared five kinds of retinoid derivative, applied each one on the wound on back of guinea pig. After 4 and 8 weeks, each wound was observed under microscope and analyzed for the amount of the collagen. RESULTS: Among the newly developed retinoid derivatives, PVP-RA(ester form) was the most effective in wound healing of the dermal damaged guinea pig. CONCLUSION: Retionid derivatives were effective in dermal wound healing if well prepared.

Keyword

Retinoid; Wound healing

MeSH Terms

Animals
Collagen
Diet
Guinea Pigs
Polyethylene*
Polyvinyls*
Receptors, Cytoplasmic and Nuclear
Retinoids
Skin
Tretinoin*
Vitamin A
Vitamins
Wound Healing*
Wounds and Injuries*
Collagen
Polyethylene
Polyvinyls
Receptors, Cytoplasmic and Nuclear
Retinoids
Tretinoin
Vitamin A
Vitamins