Pediatr Gastroenterol Hepatol Nutr.  2021 Mar;24(2):230-237. 10.5223/pghn.2021.24.2.230.

Polyethylene Glycol Plus Electrolytes with Stimulant Laxative in Paediatric Faecal Disimpaction: A Randomised Controlled Study

• Acharyya BC
• Bhattacharyya C
• Mukhopadhyay M
• Acharyya S

• KMID: 2513666
• DOI: http://doi.org/10.5223/pghn.2021.24.2.230

Abstract

Functional constipation is common in the paediatric population all over the world. Effective disimpaction to evacuate the impacted faecal matter forms an essential initial step in the management of constipation. Though different regimens of polyethylene glycol 3350 with electrolytes (PEG+E) are accepted as the prime medication for disimpaction, response is not always satisfactory. A randomised prospective study was undertaken, in a tertiary paediatric Gastroenterology centre to find out the outcome of a 2-day disimpaction when a stimulant laxative sodium picosulphate was added to PEG3350+E (PEG+E+PS group) and comparing it with the outcome using PEG3350+E (PEG+E group) alone. Hundred and one children were randomised into two groups to receive PEG+E+PS and PEG+E. Results revealed that PEG+E+PS group proved significantly superior to PEG+E group in most of the efficacyparameters in terms of disimpaction as well as long-term management of constipation. Though stimulant laxatives are being used for disimpaction, comparative data are lacking. This was the 1st such comparative study looking at the efficacy of these two processes of disimpaction along with long term effect on treatment.

Keyword

Paediatric; Paediatric; Functional; Functional; ConsSodium; Constipation; Polyethylene glycol+electrolytes; Polyethylene glycol+electrolytes; Faecal Incontinence; Faecal Incontinence; Laxative; Laxative; Sodium picosulphate; Sodium picosulphate