J Korean Sleep Res Soc.  2013 Dec;10(2):35-38.

Morphological Changes in Narcolepsy

Affiliations
  • 1Sleep Disorder Clinic, Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ejoo@skku.edu

Abstract

Narcolepsy is a chronic neurological disorder with the abnormal regulation of the sleep-wake cycle, resulting in excessive daytime sleepiness, disturbed nocturnal sleep, and manifestations related to rapid eye movement sleep such as cataplexy, sleep paralysis, and hypnagogic hallucination. Over the past decade, numerous neuroimaging studies, have been performed to characterize the pathophysiology and various clinical features of narcolepsy. Here we review structural findings based on brain magnetic resonance imaging in narcolepsy with cataplexy, which include voxel-based morphometry, cortical thickness analyses, and hippocampal volumetry. The current state of research suggests that structural neuroimaging is a useful tool to investigate and understand the anatomical correlates and brain abnormalities of narcolepsy.

Keyword

Narcolepsy; MRI; Morphometry; Cortical thickness; Hippocampus
Full Text Links
  • JKSRS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr