J Korean Soc Transplant.  2006 Dec;20(2):143-148.

Proliferation Signal Inhibitors: Sirolimus and Everolimus

• Kim JK

Abstract

Proliferation signal inhibitors are a new class of immunosuppressant. They inhibit the mammalian target of rapamycin and blocks the cell cycle of various cell types, including T and B lymphocytes. PSI is used in renal transplantation as a maintenance immunosuppressant. The benefit of this drug in some immunologic and malignant disease is currently under being focused. Reports of synergism with cyclosporine and tacrolimus in preclinical and clinical studies, avoidance of nephrotoxicity and possible treatment or prevention of chronic allograft nephropathy are leading to high expectations for this new class of immunosuppressant. This review summarizes preclinical and clinical results published to date and evaluates the future value of PSI for renal transplantation.

Keyword

Renal transplantation; Proliferation signal inhibitor; Nephrotoxicity

MeSH Terms

Allografts
B-Lymphocytes
Cell Cycle
Cyclosporine
Everolimus
Kidney Transplantation
Sirolimus*
Tacrolimus
Cyclosporine
Sirolimus
Tacrolimus