J Menopausal Med.  2015 Aug;21(2):115-119. 10.6118/jmm.2015.21.2.115.

Sclerosing Sromal Tumor of the Ovary in Postmenopausal Women: A Report of Two Cases

• Lee CM
• Lim S
• Cho HY
• Lee JS
• Shin JW

• KMID: 2200993
• DOI: http://doi.org/10.6118/jmm.2015.21.2.115

Abstract

Sclerosing stromal tumor (SST) was first delineated as a distinct ovarian sex cord stromal tumor in 1973 by Chalvardjian and Scully. It is a benign neoplasm, distinguished from other ovarian stromal tumors by the production of collagen and a pseudolobular pattern, and it tends to occur in the second and third decades of life in diagnosed patients. We discovered two rare cases of SST in post-menopausal women which are the topic of this report. These case studies are accompanied by a brief review of the literature.

Keyword

Menopause; Ovarian neoplasms; Sex cord-gonadal stromal tumors

MeSH Terms

Collagen
Female
Humans
Menopause
Ovarian Neoplasms
Ovary*
Sex Cord-Gonadal Stromal Tumors
Collagen

Figure

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  Fig. 1 Microscopic features of the sclerosing stromal tumor from case 1. (A) The vessels have a hemangiopericytoma-like staghorn pattern (H&E, × 400). (B) The luteinized cells are strongly immunoreactive for inhibin-alpha (× 200).

• 

  Fig. 2 Gross finding from case 2. A cystic mass with a solid portion revealing a diffuse hemorrhagic, variegated appearance. The cystic contents include dark brown serous fluid, blood clots and necrotic tissue. The solid components were fibrotic and white to yellow in appearance.

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  Fig. 3 Microscopic features of the sclerosing stromal tumor from case 2. (A) The solid area includes a pseudolobular pattern of alternating hypercellular and hypocellular areas (H&E, × 40). (B) The cellular areas are composed of dual cell populations: collagen-producing spindle cells and rounded weak lutein cells (arrow) (H&E, × 400).

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