Korean J Obstet Gynecol.  2012 Apr;55(4):261-264. 10.5468/KJOG.2012.55.4.261.

Sclerosing stromal cell tumor of the ovary in pregnancy: A case report and review of the literature

• Kim ID
• Chang HS
• Hwang KJ

• KMID: 1992623
• DOI: http://doi.org/10.5468/KJOG.2012.55.4.261

Abstract

A sclerosing stromal tumor of the ovary is an extremely rare benign tumor in pregnant women. Only 9 reports of sclerosing stromal tumor of the ovary during pregnancy have been presented. A 26-year-old woman at the 10th week of gestation was explored via laparoscopic surgery. She had non-specific symptoms but high levels of the tumor marker. The pathological diagnosis was sclerosing stromal tumor of the right ovary. We report a case of sclerosing stromal tumor in a 26-year-old woman who was admitted to confirm pregnancy with a review of the literature.

Keyword

Sclerosing stromal tumor; Pregnancy; Ovarian neoplasm

MeSH Terms

Adult
Female
Humans
Laparoscopy
Ovarian Neoplasms
Ovary
Pregnancy
Pregnant Women
Stromal Cells

Figure

• 

  Fig. 1 (A) Ultrasonography disclosed a large round mass, mainly solid and with small central hypoechoic and anechoic areas, in the right adnexal region. (B) Laparoscopic finding of the tumor reveals that it is gray-white in color and has a smooth and well-encapsulated surface.

• 

  Fig. 2 (A) Histological appearance showing the pseudolobular pattern consisting of a hypercellular (arrow) and hypocellular area (H&E, ×40). (B) Histological appearance showing the vasculated and spindled fibroblast-like cells (H&E, ×400).

Reference

1. Fefferman NR, Pinkney LP, Rivera R, Popiolek D, Hummel-Levine P, Cosme J. Sclerosing stromal tumor of the ovary in a premenarchal female. Pediatr Radiol. 2003. 33:56–58.

2. Chang W, Oiseth SJ, Orentlicher R, Agarwal G, Yahr LJ, Cayten CG. Bilateral sclerosing stromal tumor of the ovaries in a premenarchal girl. Gynecol Oncol. 2006. 101:342–345.

3. Cashell AW, Cohen ML. Masculinizing sclerosing stromal tumor of the ovary during pregnancy. Gynecol Oncol. 1991. 43:281–285.

4. Duska LR, Flynn C, Goodman A. Masculinizing sclerosing stromal cell tumor in pregnancy: report of a case and review of the literature. Eur J Gynaecol Oncol. 1998. 19:441–443.

5. Huang SC, Chen HC, Chang KC, Chou CY. Ascites and elevated androgen level in a pregnant patient with an ovarian sclerosing stromal tumor. J Formos Med Assoc. 2003. 102:124–126.

6. Ihara N, Togashi K, Todo G, Nakai A, Kojima N, Ishigaki T, et al. Sclerosing stromal tumor of the ovary: MRI. J Comput Assist Tomogr. 1999. 23:555–557.

7. Chalvardjian A, Scully RE. Sclerosing stromal tumors of the ovary. Cancer. 1973. 31:664–670.

8. Kier R, McCarthy SM, Scoutt LM, Viscarello RR, Schwartz PE. Pelvic masses in pregnancy: MR imaging. Radiology. 1990. 176:709–713.

9. Dewbury KC, Meire HB, Cosgrove DO, Farrant P. Ultrasound in obstetrics and gynaecology. 2001. 2nd ed. London: Churchill Livingstone.

10. Joja I, Okuno K, Tsunoda M, Takeda Y, Sugita K, Mizutani Y, et al. Sclerosing stromal tumor of the ovary: US, MR, and dynamic MR findings. J Comput Assist Tomogr. 2001. 25:201–206.

11. Calabrese M, Zandrino F, Giasotto V, Rissone R, Fulcheri E. Sclerosing stromal tumor of the ovary in pregnancy: clinical, ultrasonography, and magnetic resonance imaging findings. Acta Radiol. 2004. 45:189–192.

12. Damajanov I, Drobnjak P, Grizelj V, Longhino N. Sclerosing stromal tumor of the ovary: a hormonal and ultrastructural analysis. Obstet Gynecol. 1975. 45:675–679.

13. Tsukamoto N, Nakamura M, Ishikawa H. Case report: sclerosing stromal tumor of the ovary. Gynecol Oncol. 1976. 4:335–339.

14. Ho Yuen B, Robertson DI, Clement PB, Mincey EK. Sclerosing stromal tumor of the ovary. Obstet Gynecol. 1982. 60:252–256.