J Lung Cancer.  2009 Dec;8(2):114-117. 10.6058/jlc.2009.8.2.114.

Epitheilioid Trophoblastic Tumor of the Lung: A Case Report

  • 1Department of Pathology, Gachon University Gil Hospital, Incheon, Korea. syha@gilhospital.com
  • 2Department of Thoracic Surgery, Gachon University Gil Hospital, Incheon, Korea.


Epithelioid trophoblastic tumor is a rare type of gestational trophoblastic disease that is distinct from placental site trophoblastic tumor and choriocarcinoma, and epithelioid trophoblastic tumor has features resembling a carcinoma. We report here on an epithelioid trophoblastic tumor that was discovered as a solitary pulmonary nodule in the lung of a 50-year-old woman. The patient had suffered from a hydatidiform mole 20 years previously. Wedge resection of the lung was done and this showed a 1.9x1.5 cm sized, relatively well defined mass composed of mononuclear tumor cells admixed with hyaline-like material and necrosis. The tumor cells were positive for EMA, Cam5.2, alpha-inhibin, PLAP and hCG. After consulting the gynecologic department, a 7.5x6.5 cm sized mass was discovered in the uterine fundus. Hysterectomy was then done. The tumor cells were same to those of the lung mass. The lung mass is considered to be metastasis from the epithelioid trophoblastic tumor of the uterus. She has been an uneventful clinical course for three years.


Lung; Trophoblastic neoplasms; Metastasis; Gestational trophoblastic neoplasms
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