J Korean Soc Transplant.
1997 May;11(1):137-144.
Living Related Liver Transplantation
- Affiliations
-
- 1Department of Surgery, Korea University, College of Medicine, Seoul, Korea.
- 2Department of Plastic Surgery, Korea University, College of Medicine, Seoul, Korea.
- 3Department of Radiology, Korea University, College of Medicine, Seoul, Korea.
- 4Department of Anesthesiology, Korea University, College of Medicine, Seoul, Korea.
Abstract
- Human orthotopic liver transplantation was first attempted in 1963. Living related liver transplantation has been introduced by Raia in 1988. In children, biliary atresia is the leading indication of living related liver transplantation. We performed 2 cases living related liver transplantation on May, 1996. The donors were 32 and 30 year old father, recipients were his 3 year old son and 4 year old daughter. The causes of liver failure were drug induced fulminant hepatitis and recurrent cholangitis due to biliary atresia. The first case was incompatible of ABO blood typing, donor AB(Rh+) and recipient B(Rh+). The ABO incompatible donor was performed preoperatively plasmapheresis. After left lateral segmentectomy of donor and total hepatectomy of recipient, donor liver was orthotopically transplanted. The average operation time of donor and recipient were 8 hours and 12.5 hours. The amount of transfusion in donor and recipient were average 2 pints and 2.5 pints. The perioperative immunosuppression was maintained with prednisone, azathioprine and cyclosporin, but 1st case was changed from cyclosporin to OKT3 on postoperative 9th day. The postoperative complications of recipient were pulmonary edema, bacterial and fungal infection. The donors were discharged on postoperative 8th and 9th day. The first case patient was discharged postoperative 42th day due to respiratory complication. The 2nd recipient was discharged postoperative 22th day. We suggested that living related liver transplantation is good modality for resolving the graft shrtage in pediatric liver transplantation.
MeSH Terms
-
Adult
Azathioprine
Biliary Atresia
Blood Grouping and Crossmatching
Child
Child, Preschool
Cholangitis
Cyclosporine
Fathers
Hepatectomy
Hepatitis
Humans
Immunosuppression
Liver Failure
Liver Transplantation*
Liver*
Mastectomy, Segmental
Muromonab-CD3
Nuclear Family
Plasmapheresis
Postoperative Complications
Prednisone
Pulmonary Edema
Tissue Donors
Transplants
Azathioprine
Cyclosporine
Muromonab-CD3
Prednisone
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