J Korean Soc Coloproctol.  2011 Jun;27(3):133-139. 10.3393/jksc.2011.27.3.133.

Matrix Metalloproteinase-2 and -7 Expression in Colorectal Cancer

• Hong SW
• Kang YK
• Lee B
• Lee WY
• Jang YG
• Paik IW
• Lee H

• KMID: 2198761
• DOI: http://doi.org/10.3393/jksc.2011.27.3.133

Abstract

PURPOSE
Matrix metalloproteinase-2 (MMP-2) and MMP-7 have been implicated in tumor growth and metastasis. This study aimed to investigate the expressions of MMP-2 and -7 in colorectal cancer and to evaluate their values as prognostic markers.
METHODS
Immunohistochemical staining for MMP-2 and -7 was done in 144 resected colorectal cancer specimens. Clinicopathological data and survival results were compared with regard to the expression results.
RESULTS
The expression rates of MMP-2 in tumor cells in the tumor center and the tumor border were 16.7% and 38.9%, respectively. That of MMP-2 in stromal cells was 27.8%. MMP-7 immunoreactivities of tumor cells in the tumor center and the tumor border were 6.9% and 23.6%. The expressions of MMP-2 and MMP-7 were correlated. MMP-2 expression in stromal cells was more increased in the distal part of the colorectum: 8.8% in right colon cancer, 29.5% in left colon cancer and 36.4% in rectal cancer. MMP-2 expression of tumor cells in the tumor border was correlated with T-stage. MMP-7 expression of tumor cells in the tumor border was increased in case of infiltrative cancer compared with fungating tumor. The expression patterns of MMP-2 and -7 were not correlated with other clinicopathological factors, including tumor markers, node metastasis, distant metastasis, lymphatic invasion, tumor differentiation, and recurrence. No significant associations between the overall and disease-free survival rates and the MMP-2 and -7 expression patterns were noted.
CONCLUSION
The high expression rates of MMP-2 and -7 in tumor borders suggest that MMP-2 and -7 have some role in tumor invasion, but in this study, MMP-2 and -7 did not appear to be significant predictors of prognosis in colorectal cancer.

Keyword

Matrix metalloproteinases; Colorectal neoplasms; Prognosis; Immunohistochemistry

MeSH Terms

Colonic Neoplasms
Colorectal Neoplasms
Disease-Free Survival
Immunohistochemistry
Lymphatic Metastasis
Matrix Metalloproteinase 2
Matrix Metalloproteinases
Neoplasm Metastasis
Prognosis
Rectal Neoplasms
Recurrence
Stromal Cells
Biomarkers, Tumor
Matrix Metalloproteinase 2
Matrix Metalloproteinases
Tumor Markers, Biological